ML 352 hydrochloride

Cat. No. 5725

ML 352 hydrochloride C21H29N3O4.HCl

Price and Availability

For ML 352 hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 4-Methoxy-N-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-3-[(1-methyl-4-piperidinyl)oxy]benzamide hydrochloride

Biological Activity

High affinity and selective presynaptic choline transporter (CHT) inhibitor (Ki = 92 nM). Exhibits selectivity for CHT over dopamine, serotonin and noradrenalin transporters; acetylcholinesterase and cholineacetyltransferase; and a panel of 65 other GPCRs, ion channels and transporters.

Technical Data

M.Wt:
423.93
Formula:
C21H29N3O4.HCl
Solubility:
Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Bollinger et al (2015) Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter. Bioorg.Med.Chem.Lett. 25 1757. PMID: 25801932.

Ennis et al (2015) Identification and characterization of ML352: a novel, noncompetitive inhibitor of the presynaptic choline transporter. ACS Chem.Neurosci. 6 417. PMID: 25560927.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses ML 352 hydrochloride from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: ML 352 hydrochloride, supplier, ML352, hydrochloride, 1649450-12-3, high, affinity, selective, presynaptic, choline, transporter, CHT, Tocris Bioscience, Acetylcholine Transporter products

Quick Order

Find multiple products by catalog number

divider line

Nicotinic ACh Review

Written by Susan Wonnacott

Nicotinic ACh Receptors Scientific Review

Our Nicotinic Acetylcholine Receptor review summarizes the structure and function of nAChR receptors, and the pharmacological ligands used to study them. Request copy or view PDF today.

divider line

New Products in this Area

Org 24598

Inhibitor of GlyT1; derivative of Org 24598 (Cat. No. 4035).

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.