ML 352 hydrochloride
Cat. No. 5725
Chemical Name: 4-Methoxy-N-[[3-(1-methylethyl)-5-i
Biological ActivityHigh affinity and selective presynaptic choline transporter (CHT) inhibitor (Ki = 92 nM). Exhibits selectivity for CHT over dopamine, serotonin and noradrenalin transporters; acetylcholinesterase and cholineacetyltransferase; and a panel of 65 other GPCRs, ion channels and transporters.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Bollinger et al (2015) Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter. Bioorg.Med.Chem.Lett. 25 1757. PMID: 25801932.
Ennis et al (2015) Identification and characterization of ML352: a novel, noncompetitive inhibitor of the presynaptic choline transporter. ACS Chem.Neurosci. 6 417. PMID: 25560927.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses ML 352 hydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: ML 352 hydrochloride, supplier, ML352, hydrochloride, 1649450-12-3, high, affinity, selective, presynaptic, choline, transporter, CHT, Tocris Bioscience, Acetylcholine Transporter products
Find multiple products by catalog number
New Products in this Area
Dopamine uptake inhibitorOrg 24598
Inhibitor of GlyT1; derivative of Org 24598 (Cat. No. 4035).
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.