MS 023 dihydrochloride

Cat. No. 5713new

MS 023 dihydrochloride C17H25N3O.2HCl

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Chemical Name: N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine dihydrochloride

Biological Activity

Potent and selective type I PRMT inhibitor (IC50 values are 8, 8, 30, 83 and 119 nM for PRMT6, PRMT8, PRMT1, PRMT4 and PRMT3, respectively). Exhibits no significant activity against type II and III PRMTs, PKMTs, DNMTs, KDMs and reader proteins. Reduces global arginine asymmetric dimethylation levels in vitro.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MS023 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MS023 is reviewed on the chemical probes website.

Technical Data

M.Wt:
360.32
Formula:
C17H25N3O.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Eram et al (2016) A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases. ACS Chem.Biol. 11 772. PMID: 26598975.

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Keywords: MS 023 dihydrochloride, supplier, MS023, dihydrochloride, potent, Type-1, selective, PRMT, inhibitors, inhibits, PRMT6, PRMT8, PRMT1, PRMT4, PRMT3, Tocris Bioscience, Protein Arginine Methyltransferase Inhibitor products

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