DY 268

Cat. No. 5656

DY 268 C30H32N4O5S [1609564-75-1]

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Chemical Name: 1-[(3-Methoxyphenyl)methyl]-N-[4-methyl-3-(4-morpholinylsulfonyl)phenyl]-3-(4-methylphenyl)-1H-pyrazole-4-carboxamide

Biological Activity

Potent FXR antagonist (IC50 = 7.5 nM). Exhibits no detectable cytotoxicity in cell-based assays.

Licensing Information

Sold under license from the Beckman Research Institute of the City of Hope.

Technical Data

M.Wt:
560.66
Formula:
C30H32N4O5S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1609564-75-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Yu et al (2014) Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor. Bioorg.Med.Chem. 22 2919. PMID: 24775917.

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Keywords: DY 268, supplier, DY268, farnesoid, X, receptors, antagonists, antagonism, FXR, nuclear, potent, Tocris Bioscience, LXR-like Receptor Antagonist products

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