BRD 7552

Cat. No. 5230

BRD 7552 C33H33N3O15 [1137359-47-7]

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Chemical Name: Methyl [2,3-O-bis(Benzo[1,3]dioxol-5-yl-carbamoyl)]-4-O-(4-ethoxycarbonyl-phenylcarbamoyl)-α-D-glucopyranoside

Biological Activity

PDX1 transcription factor inducer; up regulates PDX1 expression in both primary human islets and ductal cells. Induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. Increases insulin expression in PANC-1 cells, primary human islets and human duct-derived cells.

Technical Data

M.Wt:
711.63
Formula:
C33H33N3O15
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1137359-47-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Yuan et al (2013) A small-molecule inducer of PDX1 expression identified by high-throughput screening. Chem.Biol. 20 1513. PMID: 24290880.

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Keywords: BRD 7552, supplier, BRD7552, pancreatic, and, duodenal, homeobox, 1, PDX1, transcription, factor, inducers, epigenetic, insulin, diabetes, Tocris Bioscience, Other Transcription Factor products

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