NVP BHG 712

Cat. No. 4405

NVP BHG 712 C26H20F3N7O.CF3CO2H [940310-85-0]

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Chemical Name: 4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide trifluoroacetate

Biological Activity

Selective inhibitor of EphB4 kinase; exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3. Inhibits EphB4 autophosphorylation in transiently transfected HEK 293 cells. Also inhibits VEGF-induced angiogenesis in vivo; thought to inhibit EphB4 forward signaling. Orally active.

Technical Data

M.Wt:
617.5
Formula:
C26H20F3N7O.CF3CO2H
Solubility:
Soluble to 40 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
940310-85-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Wnuk et al (2012) Podocyte EphB4 signaling helps recovery from glomerular injury. Kidney Int. 81 1212. PMID: 22398409.

Martiny-Baron et al (2010) The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis. Angiogenesis. 13 259. PMID: 20803239.

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Keywords: NVP BHG 712, supplier, NVPBHG712, EphB4, kinase, inhibitors, inhibits, ephrinB2, EphB2, ephrin, VEGF, angiogenesis, antiangiogenics, ephrins, Tocris Bioscience, Eph Receptor Inhibitor products

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