Cat. No. 3819

Liquiritigenin C15H12O4 [578-86-9]

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Chemical Name: (S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Biological Activity

Potent ERβ agonist isolated from licorice root (EC50 = 36.5 nM for activation of the ERE tk-Luc reporter by ERβ in transfected U2OS cells). Displays 20-fold selectivity for ERβ; does not activate other nuclear receptors, including the androgen and glucocorticoid receptors. Displays anti-inflammatory effects.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Kim et al (2008) Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NK-kappaB-dependent iNOS and proinflammatory cytokines production. Br.J.Pharmacol. 154 165. PMID: 18332856.

Mersereau et al (2008) Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist. Mol.Cell.Endocrinol. 283 49. PMID: 18177995.

Yahara (1984) Flavonoid glucosides from licorice. Phytochemistry 23 2108.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Liquiritigenin include:

Gong et al (2014) Transcriptomic analysis identifies gene networks regulated by estrogen receptor α (ERα) and ERβ that control distinct effects of different botanical estrogens. Nucl Recept Signal 12 e001. PMID: 25363786.

Do you know of a great paper that uses Liquiritigenin from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Liquiritigenin, supplier, ERβ, ERb, ERbeta, selective, agonists, ERR, estrogen, receptors, anti-inflammatories, antiinflammatory, Tocris Bioscience, Estrogen and Related Receptor Agonist products

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