TFM-4AS-1

Cat. No. 3813

TFM-4AS-1 C27H33F3N2O2 [188589-61-9]

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Chemical Name: (1S,3aS,3bS,5aR,9aR,9bS,11aS)-6,9a,11a-Trimethyl-7-oxo-N-[2-(trifluoromethyl)phenyl]-2,3,3a,3b,4,5,5a,9b,10,11-decahydro-1H-indeno[5,4-f]quinoline-1-carboxamide

Biological Activity

Potent selective androgen receptor modulator (SARM) (IC50 = 30 nM). Steroidal compound. Exhibits limited effects on reproductive tissues and sebaceous glands; does not repress AP-1-sensitive MMP-1 reporter. Inhibits 5α-reductase type I and II (IC50 values are 2 and 3 nM respectively).

Technical Data

M.Wt:
474.56
Formula:
C27H33F3N2O2
Solubility:
Soluble to 10 mM in DMSO and to 10 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
188589-61-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Schmidt et al (2009) Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands. J.Biol.Chem. 284 36367. PMID: 19846549.

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Keywords: TFM-4AS-1, supplier, selective, androgen, receptor, modulator, AR, ligand, SARM, androgen, receptors, Tocris Bioscience, Androgen Receptor Modulator products

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