Cat. No. 3812
Chemical Name: (4aα,4bβ,6aα,7α,9aβ,9bα,11aβ)-N-(2-Chlorop
Biological ActivityPotent steroidal androgen receptor agonist (IC50 = 12 nM). Mimics the action of 5α-dihydrotestosterone (DHT). Transactivates the mouse mammary tumor virus (MMTV) promoter; represses MMP1 promoter activity. Inhibits 5α-reductase type I and II (IC50 values are 6 and 10 nM respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Schmidt et al (2009) Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands. J.Biol.Chem. 284 36367. PMID: 19846549.
Tolman et al (1997) 4-Methyl-3-oxo-4-aza-5α-androst-1-ene-17β-N-aryl-carboxamides: an approach to combined androgen blockade [5α-reductase inhibition with androgen receptor binding in vitro]. J.Steroid.Biochem.Mol.Biol. 60 303. PMID: 9219921.
If you know of a relevant reference for Cl-4AS-1 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Cl-4AS-1 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Cl-4AS-1, supplier, steroidal, androgen, receptors, agonists, Cl-4AS-1, Cl4AS1, transactivates, MMTV, inhibits, 5alpha, 5α, 5a, reductases, inhibitors, Tocris Bioscience, Androgen Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Synthetic progesterone analogC-DIM 12
Nurr1 activator; inhibits NF-κB-dependent gene expression(S)-Equol
Potent estrogen receptor β (ERβ) agonistAilanthone
Potent inhibitor of androgen receptor (AR)(±)-ML 209
RORγt inverse agonist; suppresses Th17 cell differentiationAGN 193109
High affinity pan-RAR antagonistSR 9243
Selective LXR inverse agonist
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.