N1,N12-Diethylspermine tetrahydrochloride

Cat. No. 0500

N1,N12-Diethylspermine tetrahydrochloride C14H34N4.4HCl [113812-15-0]

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Biological Activity

Powerful antineoplastic agent in cultured cells and animal tumors (IC50 = 0.2 μM in L1210 cells). Inhibitor of polyamine synthases. Suppressor of mitochondrial DNA synthesis.

Technical Data

Soluble to 100 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Bergeron et al (2005) Synthesis and bioloigcal evaluation of aminopolyamines. J.Med.Chem. 48 3099. PMID: 15857111.

Vertino et al (1991) Selective cellular depletion of mitochondrial DNA by the polyamine analog N1,N12-bis(ethyl)spermine and its relationship to polyamine structure and function. Mol.Pharmacol. 39 487. PMID: 2017149.

Porter et al (1990) Combined regulation of arginine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N1,N12-bis(ethyl)spermine. Biochem.J. 268 207. PMID: 2344358.

Bergeron et al (1988) Synthetic polyamine analogues as antineoplastics. J.Med.Chem. 31 1183. PMID: 3373487.

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Keywords: N1,N12-Diethylspermine tetrahydrochloride, supplier, Polyamine, synthase, inhibitors, inhibits, Synthases, Synthetases, Tocris Bioscience, Other Synthase/Synthetase Inhibitor products

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