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Submit ReviewIndirubin-3'-oxime
说明： GSK-3β inhibitor; also inhibits cdks and other protein kinases
别名： Indirubin-3'-monoxime
化学名： 3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
纯度： ≥99% (HPLC)
生物活性 for Indirubin-3'-oxime
Indirubin-3'-oxime is a inhibitor of GSK-3β (IC50 = 190 nM) and cyclin dependent kinases (cdks; IC50 values are 0.05, 0.18 and 0.25-0.5 βM for cdk9, cdk1 and cdk2, respectively). Also reported to inhibit AMPK, LCK and SGK. Inhibits cdk5- and GSK-3β-mediated tau phosphorylation. Induces cell cycle arrest and inhibits cell proliferation.
技术数据 for Indirubin-3'-oxime
| 分子量 | 277.28 |
| 公式 | C16H11N3O2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 160807-49-8 |
| PubChem ID | 5326739 |
| InChI Key | LDEWQRSYYHTQRA-UHFFFAOYSA-N |
| Smiles | O\N=C1C2=CC=CC=C2NC/1=C1\C(=O)NC2=C1C=CC=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Indirubin-3'-oxime
参考文献 for Indirubin-3'-oxime
参考文献是支持产品生物活性的出版物。
Bain et al (2003) The specificities of protein kinase inhibitors: an update. Biochem.J. 371 199 PMID: 12534346
Hoessel et al (1999) Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat.Cell.Biol. 1 60 PMID: 10559866
Leclerc et al (2001) Indirubins inhibit glycogen synthase kinase-3β and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. J.Biol.Chem. 276 251 PMID: 11013232
Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987
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