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Submit ReviewA 77-01
说明： Potent inhibitor of TGF-βRI
化学名： 4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]quinoline
纯度： ≥98% (HPLC)
生物活性 for A 77-01
A 77-01 is a potent TGF-βRI (ALK-5) inhibitor (IC50 = 34 nM). Inhibits TGF-β transcriptional activation. Inhibits TGF-β-induced proliferation of lung epithelial cells and SMAD phosphorylation. Inhibits TGF-β-induced epithelial-to-mesenchymal transition (EMT). Also inhibitor of p38 MAPK. Likely active metabolite of A 83-01 (Cat. No. 2939).
化合物库 for A 77-01
A 77-01 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for A 77-01
| 分子量 | 286.33 |
| 公式 | C18H14N4 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 607737-87-1 |
| PubChem ID | 10469233 |
| InChI Key | KJTYZDORHCDZPS-UHFFFAOYSA-N |
| Smiles | CC1=NC(C2=NNC=C2C3=CC=NC4=C3C=CC=C4)=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for A 77-01
参考文献 for A 77-01
参考文献是支持产品生物活性的出版物。
Tojo et al (2005) The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β. Cancer Sci. 96 791 PMID: 16271073
Sawyer et al (2003) Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain. J.Med.Chem. 46 3953 PMID: 12954047
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关键词: A 77-01, A 77-01 supplier, A77-01, A7701, transforming, growth, factor, receptor, TGF, B, beta, β, type, I, kinase, inhibitors, inhibits, potent, p38, MAPK, A, 83-01, A83-01, TGF-beta, Receptors, BMP, and, Other, Activin, 6712, Tocris Bioscience
1 篇 A 77-01 的引用文献
引用文献是使用了 Tocris 产品的出版物。 A 77-01 的部分引用包括：
Vincent W et al (2020) Interplay among p21Waf1/Cip1, MUSASHI-1 and Krüppel-like factor 4 in activation of Bmi1-CreER reserve intestinal stem cells after gamma radiation-induced injury. Sci Rep 10 18300 PMID: 33110120
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.
Pathways for A 77-01
