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Submit ReviewYH 239-EE
说明： Promotes survival of muscle stem cells (MuSCs); MDM2 inhibitor; activates p53 activity
化学名： Ethyl 3-[2-(tert-butylamino)-1-[N-(4-chlorobenzyl)formamido]-2-oxoethyl]-6-chloro-1H-indole-2-carboxylate
纯度： ≥98% (HPLC)
生物活性 for YH 239-EE
YH 239-EE is a MDM2 inhibitor. Disrupts MDM2-p53 and activates p53 activity in vitro. Prevents mitotic catastrophe and promotes survival of aged muscle stem cells (muSCs). Also inhibits proliferation of AML cells in vitro.
技术数据 for YH 239-EE
| 分子量 | 504.41 |
| 公式 | C25H27Cl2N3O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1364488-67-4 |
| PubChem ID | 56943013 |
| InChI Key | OTUBDDRFPQLPKD-UHFFFAOYSA-N |
| Smiles | CCOC(C1=C(C2=CC=C(C=C2N1)Cl)C(C(NC(C)(C)C)=O)N(C=O)CC3=CC=C(C=C3)Cl)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for YH 239-EE
参考文献 for YH 239-EE
参考文献是支持产品生物活性的出版物。
Huang et al (2014) Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities. ACS Chem.Biol. 9 802 PMID: 24405416
Liu et al (2018) Impaired notch signaling leads to a decrease in p53 activity and mitotic catastrophe in aged muscle stem cells. Cell Stem Cell. 23 544 PMID: 30244867
关键词: YH 239-EE, YH 239-EE supplier, YH239-EE, muscle, stem, cells, MuSC, survival, proliferation, mdm2, inhibitors, inhibits, Stem, Cell, Proliferation, Ubiquitin, E3, Ligases, 6719, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.