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Cat.No. 1554 - Piceatannol | C14H12O4 | CAS No. 10083-24-6
说明: Inhibits TNF-induced NF-κB activation
化学名: 4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,2-benzenediol
纯度: ≥98% (HPLC)
引用文献 (8)
文献 (3)
通路 (1)

生物活性 for Piceatannol

Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. Inhibits p56lck and syk protein tyrosine kinases and inhibits TNF-induced NF-κB activation and gene expression. Synthesis results from conversion of resveratrol (Cat. No. 1418) by cytochrome P450 1B1.

技术数据 for Piceatannol

分子量 244.25
公式 C14H12O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 10083-24-6
PubChem ID 667639
Smiles OC1=CC(\C=C\C2=CC(O)=C(O)C=C2)=CC(O)=C1


Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Piceatannol

溶剂 最高浓度 mg/mL 最高浓度 mM
ethanol 24.43 100
DMSO 24.43 100

制备储备液 for Piceatannol

以下数据基于产品分子量 244.25。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.09 mL 20.47 mL 40.94 mL
5 mM 0.82 mL 4.09 mL 8.19 mL
10 mM 0.41 mL 2.05 mL 4.09 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

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产品说明书 for Piceatannol


参考文献 for Piceatannol


Ashikawa et al (2002) Piceatannol inhibits TNF-induced NF-kB activation and NF-kB-mediated gene expression through suppression of IkBa kinase and p65 phosphorylation. J.Immunol. 169 6490 PMID: 12444159

Geahlen and McLaughlin (1989) Piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor. Biochem.Biophys.Res.Commun. 165 241 PMID: 2590224

Oliver et al (1994) Inhibition of mast cell FceR1-mediated signalling and effector function by the syk-selective inhibitor, piceatannol. J.Biol.Chem. 269 29697 PMID: 7961959

Potter et al (2002) The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1. Br.J.Cancer 86 774 PMID: 11875742

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查看全部 NF-κB and IκB Inhibitors

关键词: Piceatannol, Piceatannol supplier, Syk, p56lck, kinase, inhibitors, inhibits, TNF-induced, NF-κB, NF-kappaB, NF-kB, activation, Kinases, Nuclear, Factor, Kappa, B, Cytokine, Signaling, Signalling, Transcription, Factors, Src, Kinase, NF-kB/IkB, 1554, Tocris Bioscience

8 篇 Piceatannol 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Piceatannol 的部分引用包括:

Shin et al (2015) TH2 cells and their cytokines regulate formation and function of lymphatic vessels. Nat Commun 6 6196 PMID: 25648335

Bakema et al (2015) Antibody-opsonized bacteria evoke an inflammatory dendritic cell phenotype and polyfunctional Th cells by cross-talk between TLRs and FcRs. J Immunol 194 1856 PMID: 25582855

Farrand et al (2013) Piceatannol enhances cisp. sensitivity in ovarian cancer via modulation of p53, X-linked inhibitor of apoptosis protein (XIAP), and mitochondrial fission. J Biol Chem 288 23740 PMID: 23833193

Meyer et al (2012) A "genome-to-lead" approach for insecticide discovery: pharmacological characterization and screening of Aedes aegypti D(1)-like DA receptors. PLoS Negl Trop Dis 6 e1478 PMID: 22292096

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*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。


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Pathways for Piceatannol


NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.