主页 / 药理学 / Enzymes / Kinases / Other Kinases / Other Kinase Inhibitors / HG-9-91-01

HG-9-91-01

Cat. No. 8985 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent pan-salt inducible kinases (SIK1, SIK2 and SIK3) inhibitor. Also inhibits Lat-B-induced EP differentiation via nuclear YAP1 accumulation.
化学名： 1-(2,4-Dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)urea
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for HG-9-91-01

HG-9-91-01 is a potent pan-salt inducible kinases (pan-SIKs) inhibitor (IC50 values are 0.92, 6.6 and 9.6 nM for SIK1, SIK2 and SIK3 respectively). HG-9-91-01 inhibits latrunculin B (Lat-B)-induced endocrine progenitors (EP) differentiation via nuclear YAP1 accumulation in vitro. HG-9-91-01 increases LPS-stimulated IL-10 production and suppresses pro-inflammatory cytokine secretion in vitro. HG-9-91-01 increases β-cell proliferation in vitro and in vivo (mouse, zebrafish).

技术数据 for HG-9-91-01

分子量 567.68
公式 C32H37N7O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1456858-58-4
PubChem ID 78357808
InChI Key UYUHRKLITDJEHB-UHFFFAOYSA-N
Smiles O=C(N(C1=CC=C(C=C1OC)OC)C2=CC(NC3=CC=C(N4CCN(CC4)C)C=C3)=NC=N2)NC5=C(C)C=CC=C5C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for HG-9-91-01

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 5.68 10
DMSO 56.77 100

制备储备液 for HG-9-91-01

以下数据基于产品分子量 567.68。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.76 mL 8.81 mL 17.62 mL
5 mM 0.35 mL 1.76 mL 3.52 mL
10 mM 0.18 mL 0.88 mL 1.76 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for HG-9-91-01

参考文献是支持产品生物活性的出版物。

Clark et al (2012) Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc.Natl.Acad.Sci.U.S.A. 109 16986 PMID: 23033494

Tian et al (2025) Salt-inducible kinases transduce mechanical forces into the specification of the pancreatic endocrine lineage. Stem Cell Rep. 20 102444 PMID: 40054471

Charbord et al (2021) In vivo screen identifies a SIK inhibitor that induces beta cell proliferation through a transient UPR. Nat.Metab. 3 682 PMID: 34031592

If you know of a relevant reference for HG-9-91-01, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Other Kinase Inhibitors

关键词: HG-9-91-01, HG-9-91-01 supplier, potent, pan, SIK, inhibitor, SIK1, SIK2, SIK3, salt, inducible, kinase, inhibits, differentiation, endocrine, progenitors, EP, YAP1, stem, cells, b-cells, beta-cells, β-cells, proliferation, in, vivo, HG-9-91-01, Other, Kinases, Differentiation, Products, Stem, Cell, Proliferation, 8985, Tocris Bioscience

篇 HG-9-91-01 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 HG-9-91-01 的引用文献。 您是否知道使用了 Tocris HG-9-91-01 的优秀论文？ 请告知我们.

HG-9-91-01 的评论

目前没有该产品的评论。 Be the first to review HG-9-91-01 and earn rewards!

Have you used HG-9-91-01?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review