Everolimus

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Cat.No. 6188 - Everolimus | C53H83NO14 | CAS No. 159351-69-6
说明: mTOR inhibitor; Immunosuppressant
别名: RAD001
化学名: 42-O-(2-Hydroxyethyl)rapamycin
纯度: ≥98% (HPLC)
说明书
引用文献
评论
文献 (3)
通路 (1)

生物活性 for Everolimus

Everolimus is a mTOR inhibitor. Inhibits tumor proliferation in vitro and in vivo. Inhibits VEGF-induced HUVEC proliferation in vitro, but does not affect tumor vascular permeability in mouse models. Immunosuppressant. Activates autophagy.

技术数据 for Everolimus

分子量 958.22
公式 C53H83NO14
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 159351-69-6
PubChem ID 100926147
InChI Key HKVAMNSJSFKALM-GKUWKFKPSA-N
Smiles [H][C@@]12CC[C@H]([C@@](O1)(C(C(N3CCCC[C@]3(C(O[C@@](CC([C@@H](/C=C([C@H]([C@H](C([C@@H](C[C@@H](/C=C/C=C/C=C([C@@H](OC)C2)\C)C)C)=O)OC)O)\C)C)=O)([C@@H](C[C@@H]4CC[C@H]([C@H](OC)C4)OCCO)C)[H])=O)[H])=O)=O)O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Everolimus

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 95.82 100
ethanol 95.82 100

制备储备液 for Everolimus

以下数据基于产品分子量 958.22。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.04 mL 5.22 mL 10.44 mL
5 mM 0.21 mL 1.04 mL 2.09 mL
10 mM 0.1 mL 0.52 mL 1.04 mL
50 mM 0.02 mL 0.1 mL 0.21 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for Everolimus

参考文献是支持产品生物活性的出版物。

Lane et al (2009) mTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor. Clin.Cancer Res. 15 1612 PMID: 19223496

Sedrani et al (1998) Chemical modification of rapamycin: the discovery of SDZ RAD. Transplant Proc. 30 2192 PMID: 9723437

Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316


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关键词: Everolimus, Everolimus supplier, mTOR, inhibitors, inhibits, immunosuppressants, RAD001, Autophagy, 6188, Tocris Bioscience

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Pathways for Everolimus

mTOR Signaling Pathway

mTOR Signaling Pathway

mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulates cell growth, proliferation and survival.