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Submit ReviewCiliobrevin A
说明： Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein
别名： HPI-4
化学名： 2,4-Dichloro-α-(3,4-4-oxo-2(1H)-quinazolinylidene)-β-oxobenzenepropanenitrile
纯度： ≥98% (HPLC)
生物活性 for Ciliobrevin A
Ciliobrevin A is a Hedgehog (Hh) pathway antagonist; blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo. Perturbs primary cilia formation; inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.
技术数据 for Ciliobrevin A
| 分子量 | 358.18 |
| 公式 | C17H9Cl2N3O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 302803-72-1 |
| PubChem ID | 6883982 |
| InChI Key | SESYPWCSIZUIAS-FOWTUZBSSA-N |
| Smiles | O=C(C1=CC=CC=C1N2)N/C2=C(C(C3=C(Cl)C=C(Cl)C=C3)=O)\C#N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Ciliobrevin A
参考文献 for Ciliobrevin A
参考文献是支持产品生物活性的出版物。
Hyman et al (2009) Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc.Natl.Acad.Sci.U.S.A. 106 14132 PMID: 19666565
Firestone et al (2012) Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature 484 7392 PMID: 22425997
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关键词: Ciliobrevin A, Ciliobrevin A supplier, CiliobrevinA, supplier, hedgehog, Hh, pathway, antagonists, blocks, inhibits, inhibitors, Smo, smoothened, patched, ciliogenesis, cilia, microtubules, dynein, cytoplasmic, AAA+, ATPase, HPI-4, Hedgehog, Signaling, Stem, Cell, Other, ATPases, 4529, Tocris Bioscience
7 篇 Ciliobrevin A 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Ciliobrevin A 的部分引用包括：
Poon et al (2019) Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins. Nat Commun 10 3779 PMID: 31439829
Shin et al (2015) Autophagy Regulates Formation of Primary Cilia in Mefloquine-Treated Cells. Biomol Ther (Seoul) 23 327 PMID: 26157548
Xiao et al (2018) Receptor-mediated endocytosis generates nanomechanical force reflective of ligand identity and cellular property. J Cell Physiol 233 5908-5919 PMID: 29243828
Conzemius et al (2016) ICAM-1 Binding Rhinoviruses A89 and B14 Uncoat in Different Endosomal Compartments. J Virol 90 7934 PMID: 27334586
Dong-Hyung et al (2019) Primary cilia mediate mitochondrial stress responses to promote dopamine neuron survival in a Parkinson's disease model. Cell Death Dis 10 952 PMID: 31844040
Charles E et al (2019) Measles Virus Forms Inclusion Bodies with Properties of Liquid Organelles. J Virol 93 PMID: 31375591
Hasan B et al (2020) HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science 369 PMID: 32943500
Ciliobrevin A 的评论
平均评分: 4 (Based on 1 Review.)
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Effectively inhibits Hh signaling.
By
Kishor Pant on 02/10/2023
分析类型： In Vitro
种属： Human
细胞系/组织： HepG2, and Huh,
This effectively inhibits Hh signaling. At 1 uM concentrations, we had satisfactory results with this compound.
Tested different concentrations and times for each cell for cilia imaging.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.