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SW 033291

Cat. No. 5759 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5759 has been discontinued.

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说明： High affinity 15-PGDH inhibitor; promotes hematopoiesis and hepatocyte proliferation
化学名： 2-(Butylsulfinyl)-4-phenyl-6-(2-thienyl)-thieno[2,3-b]pyridin-3-amine
纯度： ≥98% (HPLC)
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引用文献
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文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for SW 033291

SW 033291 is a high affinity 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor (Ki = 0.1 nM). Increases PGE2 levels in A549 cells in vitro, as well as in bone marrow, colon, lung and liver in mice. Promotes hematopoiesis, recovery from DSS-induced colitis, and hepatocyte proliferation after partial hepatectomy in mice.

化合物库 for SW 033291

SW 033291 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for SW 033291

分子量 412.59
公式 C21H20N2OS3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 459147-39-8
PubChem ID 3337839
InChI Key LCYAYKSMOVLVRL-UHFFFAOYSA-N
Smiles NC1=C(S(CCCC)=O)SC2=NC(C3=CC=CS3)=CC(C4=CC=CC=C4)=C21

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for SW 033291

参考文献是支持产品生物活性的出版物。

Zhang et al (2015) Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science 345 aaa2340 PMID: 26068857

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关键词: SW 033291, SW 033291 supplier, SW033291, 15-PGDH, hydroxyprostaglandin, dehydrogenase, inhibitors, inhibits, hematopoiesis, hematopoietic, hepatocyte, proliferation, PGE2, haematopoietic, stem, cells, HSC, Other, Dehydrogenases, Stem, Cell, Proliferation, Hematopoietic, Cells, 5759, Tocris Bioscience

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