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Submit ReviewSM 102 最新
说明： Cationic ionizable lipid
化学名： 1-Octylnonyl 8-[(2-hydroxyethyl)[6-oxo-6-(undecyloxy)hexyl]amino]octanoate
纯度： ≥95% (HPLC)
生物活性 for SM 102
SM 102 is an ionizable cationic lipid (pKa = 6.68) used in the formulation of lipid nanoparticles (LPNs) for the delivery of mRNA in vitro and in vivo. Administration of LNPs containing SM 102 induces hepatic luciferase expression in mice. SM 102 is commonly formulated with cholesterol (Cat. No. 7945), DSPC (Cat. No. 7943), and DMG-PEG 2000 (Cat. No. 7944).
For more information on LNPs and available components see our Lipid Nanoparticles page.
技术数据 for SM 102
| 分子量 | 710.17 |
| 公式 | C44H87NO5 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 2089251-47-6 |
| PubChem ID | 126697616 |
| InChI Key | BGNVBNJYBVCBJH-UHFFFAOYSA-N |
| Smiles | O=C(OCCCCCCCCCCC)CCCCCN(CCO)CCCCCCCC(=O)OC(CCCCCCCC)CCCCCCCC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SM 102
| 溶解性 | Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 100mg/mL) |
产品说明书 for SM 102
参考文献 for SM 102
参考文献是支持产品生物活性的出版物。
Hassett et al (2019) Optimization of lipid nanoparticles for intramuscular administration of mRNA vaccines. Mol Ther Nucleic Acids 15 1 PMID: 30785039
Sabnis et al (2018) A novel amino lipid series for mRNA delivery: improved endosomal escape and sustained pharmacology and safety in non-human primates. Mol.Ther. 26 1509 PMID: 29653760
If you know of a relevant reference for SM 102, please let us know.
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