主页 / 细胞生物学 / Cell Metabolism / DNA, RNA and Protein Synthesis / DNA, RNA and Protein Synthesis Inhibitors / Lin28 1632

Lin28 1632

Cat. No. 6068 3 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6068 has been discontinued.

View all DNA, RNA and Protein Synthesis products.
说明： RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor
化学名： N-Methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论 (1)
文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for Lin28 1632

Lin28 1632 is an RNA binding protein Lin28 inhibitor (IC50 = 8 μM). Lin28 1632 blocks binding of Lin28 to let-7 pre-micro RNA. Lin28 1632 inhibits stemness and induces differentiation of murine ESCs. Lin28 1632 increases let-7 miRNA and suppresses PD-L1 expression in multiple human cancer cell lines. Lin28 1632 inhibits growth of tumor cell lines and tumor-sphere formation in vitro. Lin28 1632 also inhibits growth of tumor xenografts in mice by enhancing T cell-mediated antitumor immunity. Lin28 1632 is also bromodomain inhibitor. Lin28 1632 inhibits tumor growth and metastasis in vivo in immunodeficient orthotopic mouse models of human breast cancer cell MDA-MB-231.

化合物库 for Lin28 1632

Lin28 1632 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Lin28 1632

分子量 281.31
公式 C15H15N5O
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 108825-65-6
PubChem ID 2737312
InChI Key WPAQLESUVYGUJZ-UHFFFAOYSA-N
Smiles CN(C1=CC=CC(C2=NN3C(C)=NN=C3C=C2)=C1)C(C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Lin28 1632

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Lin28 1632

参考文献是支持产品生物活性的出版物。

Roos et al (2016) A small-molecule inhibitor of Lin28. ACS Chem.Biol. 11 2773 PMID: 27548809

Chen et al (2019) LIN28/ let-7/PD-L1 pathway as a target for cancer immunotherapy. Cancer Immunol.Res. 7 487 PMID: 30651289

Chen et al (2019) Targeting LIN28B reprograms tumor glucose metabolism and acidic microenvironment to suppress cancer stemness and metastasis. Oncogene 38 4527 PMID: 30742065

按标靶查看相关产品

按产品操作查看相关产品

查看全部 DNA, RNA and Protein Synthesis Inhibitors

关键词: Lin28 1632, Lin28 1632 supplier, Lin281632, RNA-binding, protein, Lin28, stem, cell, differentiation, bromodomains, inhibitors, inhibits, PD-L1, let-7, antitumor, immunity, Bromodomains, DNA,, RNA, and, Protein, Synthesis, ESCs, iPSC, Immune, Checkpoints, 6068, Tocris Bioscience

3 篇 Lin28 1632 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Lin28 1632 的部分引用包括：

Yoji et al (2021) Lin28A/let-7 oncogenic circuit is a potential therapeutic target in neurocutaneous melanosis-associated CNS tumors in children. Neurooncol Adv 3 vdaa174 PMID: 33506207

Alfredo et al (2020) Functional Characterization of the Lin28/let-7 Circuit During Forelimb Regeneration in Ambystoma mexicanum and Its Influence on Metabolic Reprogramming. Front Cell Dev Biol 8 562940 PMID: 33330447

Miguel N et al (2020) LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma LIN28B Control of EWS-FLI1 Stability. Cell Rep 30 4567-4583.e5 PMID: 32234488

Lin28 1632 的评论

平均评分: 5 (Based on 1 Review.)

5 星
100%
4 星
0%
3 星
0%
2 星
0%
1 星
0%

Have you used Lin28 1632?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Good inhibitor for Lin28.
By Satbir Thakur on 05/17/2021
分析类型： In Vitro
种属： Human
细胞系/组织： YP-MEL, T47D and BT183

Used as an inhibitor for Lin28 for 96 h in cell lines expressing Lin28. The protein level was then estimated using a western blot method.

PMID: 33506207 参考文献
review image

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Huntington's Disease Research Product Guide

Huntington's Disease Research Product Guide

This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:

  • Somatic Instability
  • Proteolysis and Inclusion Bodies
  • Transcriptional Dysregulation
  • Mitochondrial Dysfunction
  • Nuclear-Cytoplasmic Transport Interference
  • Excitotoxicity
  • Stem Cells