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Submit ReviewSelective peptide inhibitor of glycogen synthase kinase-3 (GSK-3). Produces antidepressive behavior in mice when administered in vivo. Shows no inhibition of PKC, PKB or cdc2 protein kinase. Exhibits insulin mimetic activity. Activates glycogen synthase activity 2.5-fold in HEK293 cells.
Sold under licence from Tel Aviv University Future Technology LP.
分子量 | 1464.64 |
公式 | C66H110N15O20P |
序列 |
GKEAPPAPPQSP (Modifications: Gly-1 = Myr-Gly, Pro-12 = C-terminal amide, Ser-11 = pSer) |
储存 | Store at -20°C |
CAS Number | 1043881-55-5 |
Smiles | CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](COP(O)(O)=O)C(=O)N1CCC[C@H]1C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Chen et al (2004) Glycogen syntase kinase 3β (GSK3β) mediates 6-hydroxyDA-induced neuronal death. FASEB J. 18 1162 PMID: 15132987
Kaidanovich-Beilin et al (2004) Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effects on β-catenin in mouse hippocampus. Biol.Psychiatry 55 781 PMID: 15050857
Plotkin et al (2003) Ins mimetic action of synthetic phosphorylated peptide inhibitiors of glycogen synthase kinase-3. J.Pharm.Exp.Ther. 305 974
关键词: L803-mts, L803-mts supplier, L803-mts, peptides, inhibitors, glycogen, synthase, kinase-3, GSK-3, GSK3, inhibits, myristotylated, Glycogen, Synthase, Kinase, 3, 2256, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 L803-mts 的部分引用包括:
Hill et al (2015) Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter. Int J Obes (Lond) 45 1103 PMID: 25627813
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.