L803-mts

Discontinued Product

2256 has been discontinued.

View all Glycogen Synthase Kinase 3 products.
说明: Selective inhibitor of GSK-3
说明书
引用文献 (1)
评论
文献 (4)
通路 (1)

生物活性 for L803-mts

Selective peptide inhibitor of glycogen synthase kinase-3 (GSK-3). Produces antidepressive behavior in mice when administered in vivo. Shows no inhibition of PKC, PKB or cdc2 protein kinase. Exhibits insulin mimetic activity. Activates glycogen synthase activity 2.5-fold in HEK293 cells.

许可信息

Sold under licence from Tel Aviv University Future Technology LP.

技术数据 for L803-mts

分子量 1464.64
公式 C66H110N15O20P
序列 GKEAPPAPPQSP

(Modifications: Gly-1 = Myr-Gly, Pro-12 = C-terminal amide, Ser-11 = pSer)

储存 Store at -20°C
CAS Number 1043881-55-5
Smiles CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](COP(O)(O)=O)C(=O)N1CCC[C@H]1C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for L803-mts

参考文献是支持产品生物活性的出版物。

Chen et al (2004) Glycogen syntase kinase 3β (GSK3β) mediates 6-hydroxyDA-induced neuronal death. FASEB J. 18 1162 PMID: 15132987

Kaidanovich-Beilin et al (2004) Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effects on β-catenin in mouse hippocampus. Biol.Psychiatry 55 781 PMID: 15050857

Plotkin et al (2003) Ins mimetic action of synthetic phosphorylated peptide inhibitiors of glycogen synthase kinase-3. J.Pharm.Exp.Ther. 305 974

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关键词: L803-mts, L803-mts supplier, L803-mts, peptides, inhibitors, glycogen, synthase, kinase-3, GSK-3, GSK3, inhibits, myristotylated, Glycogen, Synthase, Kinase, 3, 2256, Tocris Bioscience

1 篇 L803-mts 的引用文献

引用文献是使用了 Tocris 产品的出版物。 L803-mts 的部分引用包括:

Hill et al (2015) Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter. Int J Obes (Lond) 45 1103 PMID: 25627813


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