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KU 0060648

Cat. No. 4840 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4840 has been discontinued.

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说明： Dual DNA-PK and PI 3-K inhibitor
化学名： 4-Ethyl-N-[4-[2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piperazineacetamide
纯度： ≥97% (HPLC)
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引用文献
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文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for KU 0060648

KU 0060648 is a dual PI 3-K and DNA-PK inhibitor (IC50 values are <0.1, 0.5, 4 and 19 nM for PI 3-Kδ, PI 3-Kβ, PI 3-Kα and DNA-PK respectively). Inhibits proliferation of MCF7 cells in vitro and delays growth of MCF7 xenografts in mice. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency ~2 to 4-fold, and decreases nonhomologous end-joining (NHEJ) frequency ~40%; maximum effect seen at 250 nM.

许可信息

Sold under license from Cancer Research Technology Ltd.

技术数据 for KU 0060648

分子量 582.71
公式 C33H34N4O4S
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 881375-00-4
PubChem ID 11964036
InChI Key AATCBLYHOUOCTO-UHFFFAOYSA-N
Smiles O=C1C3=C(C(C4=CC=C(NC(CN7CCN(CC)CC7)=O)C5=C4SC6=C5C=CC=C6)=CC=C3)OC(N2CCOCC2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for KU 0060648

参考文献是支持产品生物活性的出版物。

Munck et al (2012) Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K. Mol.Cancer Ther. 11 1789 PMID: 22576130

Dumont et al (2009) Radiosensitising agents for the radiotherapy of cancer: novel molecularly targeted approaches. Expert Opin.Ther.Patents 19 775 PMID: 19456277

Robert et al (2015) Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing. Genome Med. 7 93 PMID: 26307031

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关键词: KU 0060648, KU 0060648 supplier, KU0060648, antitumor, antitumour, PI, 3-K, phosphoinositide, 3-kinases, inhibits, inhibitors, DNA-PK, DNA-dependent, protein, CRISPR, Cas9, HDR, NHEJ, homology, directed, repair, nonhomologous, end, joining, hematopoietic, haematopoietic, stem, cells, HSC, Protein, Kinase, 3-Kinase, Checkpoint, Control, Kinases, Reagents, Hematopoietic, Stem, Cells, 4840, Tocris Bioscience

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