Hemopressin (rat)

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Cat.No. 1764 - Hemopressin (rat) | Pro-Val-Asn-Phe-Lys-Phe-Leu-Ser-His | CAS No. 568588-77-2
说明: Selective CB1 inverse agonist
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引用文献
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文献 (6)

生物活性 for Hemopressin (rat)

Hemopressin (rat) is a bioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB1 receptor inverse agonist. Displays antinociceptive activity and induces hypophagia in vivo.

技术数据 for Hemopressin (rat)

分子量 1088.27
公式 C53H77N13O12
序列 PVNFKFLSH
储存 Desiccate at -20°C
CAS Number 568588-77-2
PubChem ID 44560117
InChI Key DUTLYPZZJJBEAJ-QISMNGAHSA-N
Smiles [H]N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Hemopressin (rat)

溶解性 Soluble to 2 mg/ml in 20% acetonitrile

产品说明书 for Hemopressin (rat)

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参考文献 for Hemopressin (rat)

参考文献是支持产品生物活性的出版物。

Heimann et al (2007) Hemopressin is an inverse agonist of CB1 cannabinoid receptors. Proc.Natl.Acad.Sci.U.S.A. 104 20588 PMID: 18077343

Rioli et al (2003) Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme. J.Biol.Chem. 278 8547 PMID: 12500972

Todd et al (2010) The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice. J.Neurosci. 30 7369 PMID: 20505104


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关键词: Hemopressin (rat), Hemopressin (rat) supplier, Bioactive, endopeptidase, 2415, neurolysin, ACE, Angiotensin-Converting, Enzyme, Proteinases, Proteases, Substrates, activators, cannabinoids, receptors, CB1, inverse, agonists, antagonists, cb1r, /, Activators, Other, Receptors, 1764, Tocris Bioscience

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