Cyclo(-RGDfK) 最新

Cat. No. 8917 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent integrin inhibitor (αvβ3/αvβ6); also improves stem cell attachment in 3D cell culture scaffolds

纯度： ≥95% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Cyclo(-RGDfK)

Cyclo(-RGDfK) is a cyclic peptide, potent integrin inhibitor (IC₅₀ values are 2.3 and 55 nM for αvβ3 and αvβ6, respectively). Cyclo(-RGDfK) improves human pluripotent stem cell (hPSC) adhesion and proliferaton on 3D cell culture synthetic surfaces. Can also be used to target fluorophores and cargo to cancer cells as αvβ3 integrin is upregulated on cancer cells.

技术数据 for Cyclo(-RGDfK)

分子量	603.68
公式	C₂₇H₄₁N₉O₇
序列	RGDFK (Modifications: Lactam bridge: Arg-1 to Lys-5, Phe-4:D-Phe)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	161552-03-0
PubChem ID	10196873
InChI Key	NVHPXYIRNJFKTE-HAGHYFMRSA-N
Smiles	O=C(NCC(N[C@@H](CC(O)=O)C(N[C@H](CC1=CC=CC=C1)C(N[C@H]2CCCCN)=O)=O)=O)[C@H](CCCNC(N)=N)NC2=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Cyclo(-RGDfK)

溶解性	Soluble to 1 mg/ml in water

产品说明书 for Cyclo(-RGDfK)

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Cyclo(-RGDfK)

参考文献是支持产品生物活性的出版物。

Yu et al (2017) Oxidation of KCNB1 potassium channels triggers apoptotic integrin signaling in the brain. Cell Death Dis. 8 e2737 PMID: 28383553

Lambshead et al (2018) Long-term maintenance of human pluripotent stem cells on cRGDfK-presenting synthetic surfaces. Sci.Rep. 8 701 PMID: 29335618

Kapp et al (2017) A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins. Sci Rep 7 39805 PMID: 28074920

Gamage et al (2021) Comparison of cRGDfK peptide probes with appended shielded heptamethine cyanine dye (s775z) for near infrared fluorescence imaging of cancer. ACS Omega 6 30130 PMID: 34778684

If you know of a relevant reference for Cyclo(-RGDfK), please let us know.

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关键词: Cyclo(-RGDfK), Cyclo(-RGDfK) supplier, peptide, integrin, binding, cell, adhesion, 3D, culture, stem, cells, hPSC, proliferation, potent, inhibitors, inhibits, inhibition, biomaterials, Integrins, Cell, Adhesion, Molecules, Stem, Proliferation, 8917, Tocris Bioscience

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