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CX-4945

Cat. No. 8993 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective CK2α and CK2α' inhibitor. Also blocks CK2-dependent HIF-1α transcription, causes cell-cycle arrest, induces apoptosis in cancer cells and induces stem cell reprogramming
别名： Silmitasertib
化学名： Sodium 5-[(3-Chlorophenyl)amino]benzo[c]-2,6-naphthyridine-8-carboxylate
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CX-4945

CX-4945 (Silmitasertib) is a potent and selective inhibitor of protein kinase CK2α and CK2α' (IC50 = 1 nM). It shows greater than 500-fold selectivity for CK2 over a panel of > 200 kinases.

CX-4945 can be used, in combination with other small molecules, in fast chemical reprogramming protocols for the induction of human somatic cells and highly efficient generation of pluripotent stem cells (hCiPS) in a minimum of 16 days with robust repeatability and reliability.

CX-4945 has antiproliferative effects in vitro as it attenuates PI3K/Akt signalling, causes cell-cycle arrest and selectively induces apoptosis in cancer cells. In models of angiogenesis, CX-4945 inhibits human umbilical vein endothelial cell migration, tube formation, and blocks CK2-dependent hypoxia-induced factor 1 alpha (HIF-1α) transcription in cancer cells.

In vivo, CX-4945 displays robust antitumor activity with concomitant reduction of the mechanism-based biomarker phospho-p21 (T145) (murine xenograft model). CX-4945 is orally bioavailable.

技术数据 for CX-4945

分子量 371.76
公式 C19H11ClN3O2Na
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1309357-15-0
InChI Key ODDAAPQSODILSN-UHFFFAOYSA-M
Smiles O=C(C1=CC(N=C(C2=C3C=NC=C2)NC4=CC(Cl)=CC=C4)=C3C=C1)O[Na]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CX-4945

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 37.18 100
DMSO 37.18 100

制备储备液 for CX-4945

以下数据基于产品分子量 371.76。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.45 mL 26.9 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.34 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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参考文献 for CX-4945

参考文献是支持产品生物活性的出版物。

Siddiqui-Jain et al (2010) CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. Cancer Res. 70 10288 PMID: 21159648

Liuyang et al (2023) Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming. Cell Stem Cell 30 450 PMID: 36944335

Wang et al (2025) A rapid chemical reprogramming system to generate human pluripotent stem cells. Nat.Chem.Biol. 21 1030 PMID: 39753706

If you know of a relevant reference for CX-4945, please let us know.

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets