6'-GNTI dihydrochloride

Name: 6'-GNTI dihydrochloride
Brand: Tocris Bioscience
SKU: 2962
Rating: 5 (1 reviews)

Cat. No. 2962 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2962 has been discontinued.

说明： Selective κ/δ opioid heterodimer receptor agonist

别名： 6'-Guanidinonaltrindole dihydrochloride

化学名： 6''-Guanidinyl-17-(cyclopropylmethyl)-6,7-dehydro-4,5a-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan dihydrochloride

纯度： ≥97% (HPLC)

说明书

引用文献

文献 (2)

生物活性技术数据说明书参考文献

生物活性 for 6'-GNTI dihydrochloride

6'-GNTI dihydrochloride is a selective κ/δ-opioid heterodimer receptor agonist (EC₅₀ = 39.8, 112.5 and > 1000 nM for κ/δ, κ/μ and δ/μ respectively) that has no effect on opioid receptor homodimers (EC₅₀ > 1000 nM). Displays tissue-specific analgesic effects in vitro.

技术数据 for 6'-GNTI dihydrochloride

分子量	544.48
公式	C₂₇H₂₉N₅O₃.2HCl
储存	Store at -20°C
纯度	≥97% (HPLC)
PubChem ID	90488790
InChI Key	OCMMBKYOHYNDPT-GXOQRFFGSA-N
Smiles	OC1=CC=C2CC([C@@]3(O)[C@@]4(CC5)C2=C1O[C@H]4C(NC6=C7C=CC(NC(N)=N)=C6)=C7C3)N5CC8CC8.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for 6'-GNTI dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 6'-GNTI dihydrochloride

参考文献是支持产品生物活性的出版物。

Sharma et al (2001) Transformation of a κ-opoid receptor antagonist to a κ-agonist by transfer of a guanidinium group from the 5' to 6' position of naltrindole. J.Med.Chem. 44 2073 PMID: 11405645

Waldhoer et al (2005) A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers. Proc.Natl.Acad.Sci.USA 102 9050

Rozenfeld et al (2006) Heterodimers of G protein-coupled receptors as novel and distinct drug targets. Drug Discov.Today Ther.Strateg. 3 437

Rives et al (2012) 6'-guanidinonaltrindole (6'-GNTI) is a G protein-biased κ-opioid receptor agonist that inhibits arrestin recruitment. J.Biol.Chem. 287 27050 PMID: 22736766

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关键词: 6'-GNTI dihydrochloride, 6'-GNTI dihydrochloride supplier, Selective, kappa/δ-opioid, delta-opioid, κ-opioid, kappa-opioid, heterodimer, receptor, agonists, KOP, Receptors, OP2, DOP, OP1, 6'-Guanidinonaltrindole, dihydrochloride, Kappa, Opioid, Delta, 2962, Tocris Bioscience

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Good product..

By Anonymous on 01/14/2020

分析类型： In Vitro

种属： Human

Successfully induced ERK1/2 phosphorylation in CHO cells expressing KOR. It’s a very reliable compound.

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