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Submit ReviewU 90042
说明： GABAA ligand
化学名： 11-Chloro-5-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-2,3-dihydrodiimidazo[1,5-a:1',2'-c]quinazoline
纯度： ≥99% (HPLC)
生物活性 for U 90042
U 90042 is a GABAA receptor ligand that binds with comparable affinities to three receptor subtypes: α1β2γ2, α3β2γ2 and α6β2γ2 (Ki values are 7.8, 9.5 and 11.0 nM respectively). Potentiates GABA-induced chloride currents in α6β2γ2 receptors. Sedative/hypnotic compound.
技术数据 for U 90042
| 分子量 | 352.78 |
| 公式 | C17H13ClN6O |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 134516-99-7 |
| PubChem ID | 9928470 |
| InChI Key | CLPSAAPUJUVQPP-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C4C(C2=NCCN2C(N4C=N5)=C5C3=NOC(C6CC6)=N3)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for U 90042
参考文献 for U 90042
参考文献是支持产品生物活性的出版物。
Tang et al (1995) U-90042, a sedative/hypnotic compound that interacts differentially with the GABAA receptor subtypes. J.Pharmacol.Exp.Ther. 275 761 PMID: 7473164
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关键词: U 90042, U 90042 supplier, GABAA, receptor, ligands, Receptors, U90042, 2733, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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