主页 / 药理学 / Nuclear Receptors / Nerve Growth Factor IB-like Receptors / Nerve Growth Factor IB-like Receptor Agonists / THPN

THPN

Cat. No. 6017 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6017 has been discontinued.

View all Nerve Growth Factor IB-like Receptors products.
说明： Nur77 agonist; induces autophagy in melanoma cell lines
化学名： 1-(3,4,5-Trihydroxyphenyl)-1-nonanone
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for THPN

THPN is a Nur77 agonist. Binds Nur77 and promotes translocation of the receptor to the mitochondria resulting in autophagy in melanoma cell lines.

技术数据 for THPN

分子量 266.33
公式 C15H22O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 100079-26-3
PubChem ID 3063200
InChI Key NVFRHTFJDGAFQS-UHFFFAOYSA-N
Smiles CCCCCCCCC(C1=CC(O)=C(C(O)=C1)O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for THPN

参考文献是支持产品生物活性的出版物。

Wang et al (2014) Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat.Chem.Biol. 10 133 PMID: 24316735

Li et al (2015) Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat.Chem.Biol. 11 339 PMID: 25822914

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Nerve Growth Factor IB-like Receptor Agonists

关键词: THPN, THPN supplier, Nur77, agonist, agonism, binds, TR3, NGFIB, autophagy, GFRP1, Nerve, Growth, Factor, IB-like, Receptors, 6017, Tocris Bioscience

篇 THPN 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 THPN 的引用文献。

THPN 的评论

目前没有该产品的评论。 Be the first to review THPN and earn rewards!

Have you used THPN?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for THPN

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.
NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.