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Submit ReviewTC-N 22A
Discontinued Product
4370 has been discontinued.
View all Glutamate (Metabotropic) Group III Receptors products.
说明： Potent and selective positive allosteric modulator of mGlu4 receptors
化学名： 4,5,6,8-Tetrahydro-N-2-pyridinylpyrazolo[3',4':6,7]cyclohepta[1,2]thiazol-2-amine
纯度： ≥98% (HPLC)
生物活性 for TC-N 22A
TC-N 22A is a potent and selective mGlu4 receptor positive allosteric modulator (EC50 = 9 nM in human mGlu4-expressing BHK cells). Selective for mGlu4 over mGlu1, mGlu2, mGlu3, mGlu5 and mGlu7 receptors (EC50 values are > 10 μM). Brain penetrant.
技术数据 for TC-N 22A
| 分子量 | 283.35 |
| 公式 | C14H13N5S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1314140-00-5 |
| PubChem ID | 46836562 |
| InChI Key | DBISXWCOHGUFSF-UHFFFAOYSA-N |
| Smiles | C2(SC(NC4=NC=CC=C4)=N3)=C3C1=CNN=C1CCC2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TC-N 22A
参考文献 for TC-N 22A
参考文献是支持产品生物活性的出版物。
Hong et al (2011) Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators. J.Med.Chem. 54 5070 PMID: 21688779
关键词: TC-N 22A, TC-N 22A supplier, metabotropics, glutamate, 4, receptors, positive, allosteric, modulators, brain, penetrant, mglur4, mglu, pams, TC-N22A, Glutamate, (Metabotropic), Group, III, Receptors, 4370, Tocris Bioscience
1 篇 TC-N 22A 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TC-N 22A 的部分引用包括：
Chiu et al (2019) NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content. Cell Rep 28 332 PMID: 31291571
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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