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Submit ReviewTAN 452
Discontinued Product
6729 has been discontinued.
说明： Potent and selective peripherally acting δ opioid antagonist; antianalgesic.
化学名： Ethyl (4bS,8R,8aS,14bR)-7-(cyclopropylmethyl)-5,6,7,8,8a,9,14,14b-octahydro-1,8a-dihydroxy-4,8-methanobenzofuro[2,3-a]pyrido[4,3-b]carbazole-12-carboxylate
纯度： ≥98% (HPLC)
生物活性 for TAN 452
TAN 452 is a potent and selective peripherally acting δ opioid antagonist; Ki values are 0.47, 5.31 and 36.56 nM at hDOR, hKOR, and hMOR, respectively. Kb values are 0.21, 7.18 and 9.43 nM, respectively. Attenuates morphine-induced side effects in vivo. Antianalgesic.
技术数据 for TAN 452
| 分子量 | 486.56 |
| 公式 | C29H30N2O5 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 892039-23-5 |
| PubChem ID | 57614240 |
| InChI Key | JOJGLAWHRDFWNQ-KFDULEKRSA-N |
| Smiles | [H][C@@]12OC3=C(C=CC4=C3[C@@]15CCN([C@](C4)([C@@]5(CC6=C2NC7=CC(C(OCC)=O)=CC=C67)O)[H])CC8CC8)O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TAN 452
参考文献 for TAN 452
参考文献是支持产品生物活性的出版物。
Lattanzi et al (2018) In vitro and in vivo pharmacological activities of 14-O-phenylpropyloxymorphone, a potent mixed mu/delta/kappa-opioid receptor agonist with reduced constipation in mice. Front.Pharmacol. 9 10.3389/fphar.2018.0 PMID: 30233377
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关键词: TAN 452, TAN 452 supplier, TAN452, Potent, selective, peripherally, acting, delta, opioid, antagonists, antagonism, antianalgesic, Delta, Opioid, Receptors, 6729, Tocris Bioscience
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