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Submit ReviewSK 609
说明： Dopamine D3 receptor biased agonist
化学名： 2-chloro-α-methyl-benzenepropanamine hydrochloride
纯度： ≥98% (HPLC)
生物活性 for SK 609
SK 609 is a dopamine D3 receptor biased agonist. Preferentially signals via the G protein-dependent pathway (EC50 values for G protein and β-arrestin-dependent signaling are 1.1 and 50.2 μM, respectively). Exhibits selectivity for D3 over D2 receptors. Improves motor deficits in rodent Parkinson's disease models and ameliorates L-DOPA (Cat. No. 3788) induced abnormal involuntary movements.
技术数据 for SK 609
| 分子量 | 220.14 |
| 公式 | C10H14ClN.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1092797-77-7 |
| InChI Key | NVCYSMVSGDVJQR-UHFFFAOYSA-N |
| Smiles | CC(CCC1=C(C=CC=C1)Cl)N.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SK 609
参考文献 for SK 609
参考文献是支持产品生物活性的出版物。
Xu et al (2017) Functional characterization of a novel series of biased signaling dopamine D3 receptor agonists. ACS Chem.Neurosci. 8 486 PMID: 27801563
Simms et al (2016) In vivo characterization of a novel dopamine D3 receptor agonist to treat motor symptoms of Parkinson's disease. Neuropharmacology 100 106 PMID: 25896768
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关键词: SK 609, SK 609 supplier, SK609, dopamine, d3, receptor, biased, agonists, agonism, parkinsons, disease, g, protein, dependent, signaling, D3, Receptors, 7039, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.