SB 205384

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Cat.No. 1512 - SB 205384 | C17H18N2O3S | CAS No. 160296-13-9
说明: GABAA modulator; slows current decay
化学名: 4-Amino-5,6,7,8-tetrahydro-7-hydroxy-2-methyl-[1H]benzothieno[2,3-b]pyridine-3-carboxylic acid 2-butynyl ester
纯度: ≥98% (HPLC)
引用文献 (2)
文献 (7)

生物活性 for SB 205384

SB 205384 is a GABAA receptor modulator; slows current decay. Potentiates α6, α3 and α5-subunit-containing receptors (EC50 values are 280, 695 and 730 nM respectively). Displays little effect on receptors containing α1 or α2 subunits.

技术数据 for SB 205384

分子量 330.4
公式 C17H18N2O3S
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 160296-13-9
PubChem ID 197690
Smiles CC#CCOC(=O)C1=C(C)N=C2SC3=C(CCC(O)C3)C2=C1N


Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SB 205384

溶剂 最高浓度 mg/mL 最高浓度 mM
DMSO 16.52 50
1eq. HCl 33.04 100

制备储备液 for SB 205384

以下数据基于产品分子量 330.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.03 mL 15.13 mL 30.27 mL
5 mM 0.61 mL 3.03 mL 6.05 mL
10 mM 0.3 mL 1.51 mL 3.03 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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查看全部 GABAA Receptor Modulators

关键词: SB 205384, SB 205384 supplier, GABAA, receptor, modulators, slows, current, decay, Receptors, SB205384, 1512, Tocris Bioscience

2 篇 SB 205384 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SB 205384 的部分引用包括:

Heidelberg et al (2013) SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with β3 and γ2 subunits. J Pharmacol Exp Ther 347 235 PMID: 23902941

Miller et al (2010) Quantitative trait locus analysis identifies Gabra3 as a regulator of behavioral despair in mice. Sci Rep 21 247 PMID: 20512339

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