SB 203580 hydrochloride

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Cat.No. 1402 - SB 203580 hydrochloride | C21H16FN3OS.HCl | CAS No. 869185-85-3
说明: Selective inhibitor of p38 MAPK; water-soluble
化学名: 4-[5-(4-Fluorophenyl)-2-[4-(methylsulphonyl)phenyl]-1H-imidazol-4-yl]pyridine hydrochloride
纯度: ≥98% (HPLC)
说明书
引用文献 (11)
评论 (4)
文献 (4)
通路 (1)

生物活性 for SB 203580 hydrochloride

SB 203580 hydrochloride is a water-soluble salt of SB 203580 (Cat. No. 1202). Selective inhibitor of p38 mitogen-activated protein kinase (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK3β and PKBα. Shown to inhibit interleukin-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase.

许可信息

Sold with the permission of GlaxoSmithKline

技术数据 for SB 203580 hydrochloride

分子量 413.89
公式 C21H16FN3OS.HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 869185-85-3
PubChem ID 16760644
InChI Key WOSGGXINSLMASH-UHFFFAOYSA-N
Smiles Cl.CS(=O)C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=NC=C1)C1=CC=C(F)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SB 203580 hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 10.35 25

制备储备液 for SB 203580 hydrochloride

以下数据基于产品分子量 413.89。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.25 mM 9.66 mL 48.32 mL 96.64 mL
1.25 mM 1.93 mL 9.66 mL 19.33 mL
2.5 mM 0.97 mL 4.83 mL 9.66 mL
12.5 mM 0.19 mL 0.97 mL 1.93 mL

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产品说明书 for SB 203580 hydrochloride

分析证书/产品说明书
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参考文献 for SB 203580 hydrochloride

参考文献是支持产品生物活性的出版物。

Borsch-Haubold et al (1998) Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. J.Biol.Chem. 273 28766 PMID: 9786874

Cuenda et al (1995) SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364 229 PMID: 7750577

Davies et al (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 351 95 PMID: 10998351

Saklatvala et al (1996) Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen on a thromboxane analogue. J.Biol.Chem. 271 6586 PMID: 8636072


If you know of a relevant reference for SB 203580 hydrochloride, please let us know.

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查看全部 p38 MAPK Inhibitors

关键词: SB 203580 hydrochloride, SB 203580 hydrochloride supplier, Selective, inhibitors, inhibits, p38, MAPK, water-soluble, Signaling, Signalling, Mitogen-Activated, Protein, Kinases, SB203580, hydrochloride, GlaxoSmithKline, GSK, 1402, Tocris Bioscience

11 篇 SB 203580 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SB 203580 hydrochloride 的部分引用包括:

Yang et al (2017) Establishment of mouse expanded potential stem cells. Nature 550 393 PMID: 29019987

Engel et al (2006) FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction. Proc Natl Acad Sci U S A 103 15546 PMID: 17032753

Zhang et al (2018) Elevated sodium chloride drives type I IF. signaling in macrophages and increases antiviral resistance. J Biol Chem 293 1030 PMID: 29203528

Edén et al (2015) Tissue factor/factor VIIa signalling promotes cytokine-induced beta cell death and impairs glucose-stimulated Ins secretion from human pancreatic islets. Diabetologia 58 2563 PMID: 26271343


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Generation of EPS-blastoids.
By Anonymous on 02/27/2020
分析类型: In Vitro
种属: Mouse
细胞系/组织: EPS

10uM

PMID: 31626770
review image

p38 MAPK pathway does not influence the LPA induced AMPK phosphorylation in microglia cells..
By lisha joshi on 06/18/2019
分析类型: In Vitro
种属: Mouse
细胞系/组织: BV2 microglia cells

We investigate the effect of LPA on microglia metabolic states. Trying to unravel possible pathways that maybe involved in this process, we used LPAR inhibitors and downstream inhibitors of MAPKs pathway. SB 203580 was used at a concentration of 10µM yet couldn't inhibit the expression of pAMPK. However the inhibitor was well tolerated by the cells.

review image

SB 203580 ameliorates LPA-induced COX-2 expression.
By Anonymous on 12/13/2018
分析类型: In Vitro
种属: Human
细胞系/组织: Osteosarcoma

MG-63 cells were pre-incubated with 10 µM SB 203580 for 30 min followed by treatment with 10 µM LPA for 3 h to follow COX-2 expression using Western blot. SB 203580 inhibited COX-2 induction by LPA.

review image

SB 203580 blunts 15d-PGJ2 induced pp38 expression.
By Chintan Koyani on 10/13/2018
分析类型: In Vitro
种属: Mouse
细胞系/组织: HL-1 cardiomyocytes

HL-1 cells were incubated with p38 MAPK inhibitor (10 µM SB203580, 25 µMPD169316) or p42/44 MAPK kinase inhibitor (25 µM PD98059) for 30 min prior to 15dPGJ2 treatment (15 µM, 1 h). Immunoreactive bands for pp38 and pp42/44 MAPK expressions were followed by Western blot. SB203580 completely inhibited 15d-PGJ2 induced p38 phosphorylation (shown in Image).

review image

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MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.