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说明： R-Spondin-1 substitute used to initiate small intestinal organoids
化学名： 3,7-Dihydro-3,7-dimethyl-8-(2-quinolinylthio)-1H-purine-2,6-dione
纯度： ≥98% (HPLC)
生物活性 for RS 246204
RS 246204 is a R-Spondin-1 substitute. Able to initiate formation and growth of mouse intestinal organoids in media without R-Spondin-1 protein. In vivo, RS 24620 has regenerative effect in damaged intestinal epithelium mouse model.
技术数据 for RS 246204
| 分子量 | 339.37 |
| 公式 | C16H13N5O2S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 878451-87-7 |
| PubChem ID | 6485821 |
| InChI Key | UHUHSGFUUWVRBO-UHFFFAOYSA-N |
| Smiles | O=C1NC(N(C)C2=C1N(C)C(SC3=CC=C4C=CC=CC4=N3)=N2)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for RS 246204
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 1.7 | 5 |
制备储备液 for RS 246204
以下数据基于产品分子量 339.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 58.93 mL | 294.66 mL | 589.33 mL |
| 0.25 mM | 11.79 mL | 58.93 mL | 117.87 mL |
| 0.5 mM | 5.89 mL | 29.47 mL | 58.93 mL |
| 2.5 mM | 1.18 mL | 5.89 mL | 11.79 mL |
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产品说明书 for RS 246204
参考文献 for RS 246204
参考文献是支持产品生物活性的出版物。
Nam et al (2017) Effects of a small molecule R-spondin-1 substitute RS-246204 on a mouse intestinal organoid culture. Oncotarget 9 6356 PMID: 29464078
If you know of a relevant reference for RS 246204, please let us know.
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关键词: RS 246204, RS 246204 supplier, RS246204, Organoid, R-spondin1, small, intestine, enteroid, 3D, culture, stem, cells, in, vivo, Organoids, 8853, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
The Organoid Handbook
Organoids are 3D, miniature versions of organs that are generated in vitro from pluripotent stem cells or adult stem cells. A variety of organoid models are available for a wide range of organs including brain, stomach, liver, colon, pancreas, lung and prostate.This handbook includes key publications, protocols, reagents, and troubleshooting recommendations for culturing, maintenance and imaging of different types of organoids.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.