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Submit Review(R)-(-)-Ketamine hydrochloride
说明： NMDA antagonist; antidepressant; may not display psychotomimetic or addictive side effects of (S)-ketamine
化学名： (R)-(-)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
纯度： ≥99% (HPLC)
生物活性 for (R)-(-)-Ketamine hydrochloride
(R)-(-)-Ketamine hydrochloride is a NMDA antagonist (Ki = 1.4 μM); exhibits more potent and longer lasting antidepressant effects compared to its enantiomer (S)-ketamine in vivo. Also may not display the psychotomimetic or addictive side effects associated with (S)-ketamine. (R)-(-)-Ketamine hydrochloride upregulates KCNQ2 channels in mouse ventral hippocampal glutamatergic neurons in vitro and in vivo. It exerts its sustained antidepressant effetcs via KCNQ2 cell type specific regulation.
技术数据 for (R)-(-)-Ketamine hydrochloride
| 分子量 | 274.19 |
| 公式 | C13H16ClNO.HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 33795-24-3 |
| PubChem ID | 9838417 |
| InChI Key | VCMGMSHEPQENPE-BTQNPOSSSA-N |
| Smiles | O=C1[C@@](C2=CC=CC=C2Cl)(NC)CCCC1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for (R)-(-)-Ketamine hydrochloride
参考文献 for (R)-(-)-Ketamine hydrochloride
参考文献是支持产品生物活性的出版物。
Zhang et al (2014) R-(-)-ketamine shows greater potency and longer lasting antidepressant effects than S-(+)-ketamine. Pharmacol.Biochem.Behav. 116 137 PMID: 24316345
Xiong et al (2018) Comparison of rapid and long-lasting antidepressant effects of negative modulators of α5-containing GABAA receptors and (R)-ketamine in a chronic social defeat stress model. Pharmacol.Biochem.Behav. 175 139 PMID: 30359627
Zanos et al (2016) NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature 533 481 PMID: 27144355
Ebert et al (1997) Norketamine, the main metabolite of ketamine, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord. Eur.J.Pharmacol. 333 99 PMID: 9311667
Lopez et al (2022) Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2. Neuron 110 2283 PMID: 35649415
关键词: (R)-(-)-Ketamine hydrochloride, (R)-(-)-Ketamine hydrochloride supplier, NMDA, receptor, antagonists, antagonism, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, ketamine, Ketamine, and, Metabolites, 6751, Tocris Bioscience
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