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说明： α6β3γ2-selective GABAA positive allosteric modulator
别名： Compound 6
化学名： 2,5-Dihydro-7-methoxy-2-(4-methoxyphenyl)-3H-pyrazolo[4,3-c]quinolin-3-one
纯度： ≥98% (HPLC)
生物活性 for PZ-II-029
PZ-II-029 is a GABAA positive allosteric modulator. Selectively binds with high affinity to α6β3γ2 subunit-containing channels. Inhibits central and peripheral trigeminal responses in a rat migraine model.
技术数据 for PZ-II-029
| 分子量 | 321.33 |
| 公式 | C18H15N3O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 164025-44-9 |
| PubChem ID | 10426200 |
| InChI Key | CGOOCGJMECBDCB-UHFFFAOYSA-N |
| Smiles | O=C1C2=CNC3=CC(OC)=CC=C3C2=NN1C(C=C4)=CC=C4OC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PZ-II-029
参考文献 for PZ-II-029
参考文献是支持产品生物活性的出版物。
Varagic et al (2013) Subtype selectivity of α+β- site ligands of GABAA receptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors. Br.J.Pharmacol. 169 384 PMID: 23472935
Fan et al (2018) The α6 subunit-containing GABAA receptor: A novel drug target for inhibition of trigeminal activation. Neuropharmacology. 140 1 PMID: 30016665
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关键词: PZ-II-029, PZ-II-029 supplier, GABAA, modulators, modulates, selective, high, affinity, alpha6beta3gamma2, a6b3g2, α6β3γ2, migraine, Compound, 6, Receptors, 6192, Tocris Bioscience
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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