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Submit ReviewPL 017
Discontinued Product
2024 has been discontinued.
说明： Selective μ agonist
生物活性 for PL 017
Selective μ opioid receptor agonist (IC50 values are 5.5 and > 10000 nM for inhibition of 125I-FK 33,824 and 125I-DADLE binding to μ and δ sites respectively). Produces naloxone-reversible analgesia, catalepsy and hyperthermia following central administration in rats in vivo.
技术数据 for PL 017
| 分子量 | 535.64 |
| 公式 | C29H37N5O5 |
| 序列 |
YPFP (Modifications:Phe-3 = N-methyl-Phe, Pro-4 = D-Pro & C-terminal amide) |
| 储存 | Store at -20°C |
| CAS Number | 83397-56-2 |
| PubChem ID | 10437173 |
| InChI Key | JAKBYSTWCHUQOK-QORCZRPOSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PL 017
参考文献 for PL 017
参考文献是支持产品生物活性的出版物。
Chang et al (1983) Potent morphiceptin analogs: structure activity relationships and morphine-like activities. J.Pharmacol.Exp.Ther. 227 403 PMID: 6313901
Meyer and Meyer (1993) Behavioral effects of the μ-opioid peptide agonists DAMGO, DALDA and PL017 on locomotor activities. Pharmacol.Biochem.Behav. 46 391 PMID: 8265694
Xin et al (1997) Body temperature and analgesic effects of selective mu and kappa opioid receptor agonists microdialyzed into rat brain. J.Pharmacol.Exp.Ther. 281 499 PMID: 9103537
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关键词: PL 017, PL 017 supplier, mu, m, opioid, agonists, analgesia, catalepsy, hyperthermia, PL017, potent, selective, Mu, Opioid, Receptors, 2024, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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