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Submit ReviewOrphanin FQ (1-11)
说明： Potent NOP agonist; displays analgesic properties
别名： Nociceptin (1-11)
生物活性 for Orphanin FQ (1-11)
Orphanin FQ (1-11) is a peptide fragment containing amino acids 1-11 of Nociceptin (Cat. No. 0910). Potent agonist of the ORL1/KOR-3 receptor (Ki = 55 nM); displays no affinity for opioid receptors, including μ, δ, κ1 and κ3 receptors (Ki >1000 nM). Displays analgesic properties in CD-1 mice.
技术数据 for Orphanin FQ (1-11)
| 分子量 | 1098.2 |
| 公式 | C49H75N15O14 |
| 序列 | FGGFTGARKSA |
| 储存 | Store at -20°C |
| CAS Number | 178249-41-7 |
| PubChem ID | 10653748 |
| InChI Key | BBTOUBACUUPBRQ-KCKZSKPYSA-N |
| Smiles | [H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Orphanin FQ (1-11)
参考文献 for Orphanin FQ (1-11)
参考文献是支持产品生物活性的出版物。
Rossi et al (1997) Pharmacological characterization of orphanin FQ/nociceptin and its fragments. J.Pharmacol.Exp.Ther. 282 858 PMID: 9262352
Rossi et al (1998) Orphanin FQ/nociceptin analgesia in the rat. Brain Res. 792 327 PMID: 9593974
Reinscheid et al (1996) Structure-activity relationship studies on the novel neuropeptide orphanin FQ. J.Biol.Chem. 271 14163 PMID: 8662940
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关键词: Orphanin FQ (1-11), Orphanin FQ (1-11) supplier, Nociceptin, Receptors, agonists, NOP, ORL1, KOR-3, analgesic, opioid, (1-11), 3932, Tocris Bioscience
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.