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NVP BSK 805

Cat. No. 5818 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5818 has been discontinued.

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说明： Potent JAK2 inhibitor; orally bioavailable
化学名： 8-[3,5-Difluoro-4-(4-morpholinylmethyl)phenyl]-2-[1-(4-piperidinyl)-1H-pyrazol-4-yl]quinoxaline trihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for NVP BSK 805

NVP BSK 805 is a potent JAK2 inhibitor (IC50 = 0.48 nM). Exhibits >20-fold selectivity for JAK2 over TYK2, JAK3 and JAK1 (IC50 values are 10.8, 18.7 and 31.6 nM, respectively). Inhibits proliferation and induces apoptosis of JAK2V617F-bearing acute myeloid leukemia cells in vitro and in vivo. Also inhibits erythropoietin-induced polycythemia. Orally bioavailable.

化合物库 for NVP BSK 805

NVP BSK 805 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for NVP BSK 805

分子量 599.94
公式 C27H28F2N6O.3HCl
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 2320258-95-3
PubChem ID 131648244
InChI Key VWBSZLCFZWKXHV-UHFFFAOYSA-N
Smiles FC1=C(CN2CCOCC2)C(F)=CC(C3=C4C(N=CC(C5=CN(C6CCNCC6)N=C5)=N4)=CC=C3)=C1.Cl.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for NVP BSK 805

参考文献是支持产品生物活性的出版物。

Baffert et al (2010) Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Mol.Cancer Ther. 9 1945 PMID: 20587663

Pissot-Soldermann et al (2010) Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors. Bioorg.Med.Chem.Lett. 20 2609 PMID: 20231096

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关键词: NVP BSK 805, NVP BSK 805 supplier, NVPBSK805, JAK2, inhibitors, inhibits, potent, orally, bioavailable, AML, acute, myeloid, leukemia, polycythemia, JAK, Kinase, 5818, Tocris Bioscience

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Pathways for NVP BSK 805

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.