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iHAP1

Cat. No. 7303 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

7303 has been discontinued.

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说明： Allosteric activator of protein phosphatase 2A (PP2A)
化学名： (2-Chloro-10H-phenothiazin-10-yl)(4-methoxyphenyl)methanone
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for iHAP1

iHAP1 is an allosteric activator of protein phosphatase 2A (PP2A) (EC50 ~ 0.12 μM); activates PP2A-B56ε subunit. Inhibits proliferation of lymphoblastic leukemia (T-ALL) cell lines including KOPT-Ki, SUPT-13 and RPMI-8402 (IC50 values are 0.3 - 0.8 μM). Inhibits tubulin polymerization in vitro (IC50 = 0.87 μM). Blocks cell cycle causing prometaphase arrest in vitro. Inhibits T-ALL tumor growth in a transgenic zebrafish model and a mouse T-ALL xenograft model.

化合物库 for iHAP1

iHAP1 is also offered as part of the Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for iHAP1

分子量 367.85
公式 C20H14ClNO2S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 105925-39-1
PubChem ID 2359994
InChI Key CSWHYHPUEDNIQY-UHFFFAOYSA-N
Smiles COC1=CC=C(C(N2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for iHAP1

参考文献是支持产品生物活性的出版物。

Prinz et al (2011) N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J.Med.Chem. 54 4247 PMID: 21563750

Mori et al (2013) Protein phosphatase 2A as a potential target for treatment of adult T cell leukemia. Curr.Cancer Drug Targets. 13 829 PMID: 24015987

Morita et al (2020) Allosteric activators of protein phosphatase 2A display broad antitumor activity mediated by dephosphorylation of MYBL2. Cell. 181 702 PMID: 32315619

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关键词: iHAP1, iHAP1 supplier, iHAP, PP2A, allosteric, activitor, activators, PP2A-B56e, protein, phosphatase, 2A, T-ALL, prometaphase, cell, cycle, inhibitors, inhibits, Protein, Ser/Thr, Phosphatases, Cell, Cycle, Inhibitors, Microtubules, 7303, Tocris Bioscience

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