UCB 9386 最新

Cat. No. 8914 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective CNS penetrant NUAK1 inhibitor

化学名： (R)-7-(Imidazo[1,2-b]pyridazin-3-yl)-3-(6-methyl-2,6-diazaspiro[3.3]heptan-2-yl)-1-(1-phenylethyl)pyrido[3,4-b]pyrazin-2(1H)-one

纯度： ≥98% (HPLC)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for UCB 9386

UCB 9386 is a potent and selective central nervous system penetrant NUAK1 (NUAK family SnF1-like kinase-1) inhibitor (pIC₅₀= 10.1). Kinome selectivity measured in the diversity panel shows that only Jak2 and Nuak2 are inhibited more than 50% at 10 nM. In vivo, UCB 9386 exhibits high brain penetrance.

技术数据 for UCB 9386

分子量	478.56
公式	C₂₇H₂₆N₈O
储存	Store at -20°C
纯度	≥98% (HPLC)
PubChem ID	172676957
InChI Key	XYKISMBNQVUKPW-GOSISDBHSA-N
Smiles	C[C@@H](N1C(C(N2CC3(C2)CN(C3)C)=NC4=C1C=C(C5=CN=C6C=CC=NN65)N=C4)=O)C7=CC=CC=C7

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for UCB 9386

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	47.86	100
	ethanol	47.86	100

制备储备液 for UCB 9386

以下数据基于产品分子量 478.56。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.09 mL	10.45 mL	20.9 mL
5 mM	0.42 mL	2.09 mL	4.18 mL
10 mM	0.21 mL	1.04 mL	2.09 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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产品说明书 for UCB 9386

分析证书/产品说明书

化学品安全技术说明书

参考文献 for UCB 9386

参考文献是支持产品生物活性的出版物。

Poullennec et al (2024) Discovery of UCB9386: a potent, selective, and brain-penetrant Nuak1 inhibitor suitable for in vivo pharmacological studies. J Med Chem 67 20879 PMID: 39588908

If you know of a relevant reference for UCB 9386, please let us know.

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