Talampanel

Pricing Availability   Qty
Cat.No. 5032 - Talampanel | C19H19N3O3 | CAS No. 161832-65-1
说明: Non-competitive non-NMDA iGluR antagonist
别名: GYKI 53773, LY 300164
化学名: (8R)-7-Acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine
纯度: ≥98% (HPLC)
说明书
引用文献
评论
文献 (10)

生物活性 for Talampanel

Talampanel is a non-competitive AMPA/kainate receptor antagonist that displays 2.3-3-fold more potent activity than GYKI 52466 (Cat. No. 1454). Potentiates the anticonvulsive activity of antiepileptic drugs in animal models of seizures. Orally active.

化合物库 for Talampanel

Talampanel is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Talampanel

分子量 337.37
公式 C19H19N3O3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 161832-65-1
PubChem ID 164509
InChI Key JACAAXNEHGBPOQ-LLVKDONJSA-N
Smiles NC(C=C4)=CC=C4C1=NN(C(C)=O)[C@H](C)CC2=C1C=C(OCO3)C3=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Talampanel

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 33.74 100

制备储备液 for Talampanel

以下数据基于产品分子量 337.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.82 mL 29.64 mL
5 mM 0.59 mL 2.96 mL 5.93 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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参考文献 for Talampanel

参考文献是支持产品生物活性的出版物。

Czuczwar et al (1998) LY 300164, a novel antagonist of AMPA/kainate receptors, potentiates the anticonvulsive activity of antiepileptic drugs. Eur.J.Pharmacol. 359 103 PMID: 9832379

Borowicz et al (2000) The AMPA/kainate receptor antagonist, LY 300164, increases the anticonvulsant effects of D.pam. Naunyn-Schmied.Arch.Pharmacol. 361 629 PMID: 10882038

Belayev et al (2001) Talampanel, a novel noncompetitive AMPA antagonist, is neuroprotective after traumatic brain injury in rats. J.Neurotrauma 18 1031 PMID: 11686490


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关键词: Talampanel, Talampanel supplier, GYKI53773, LY300164, non-competitive, AMPA/Kainate, antagonists, Glutamate, Receptors, iGlur, Ionotropic, GYKI, 53773, LY, 300164, AMPA, Kainate, 5032, Tocris Bioscience

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