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生物活性 for Talampanel
Talampanel is a non-competitive AMPA/kainate receptor antagonist that displays 2.3-3-fold more potent activity than GYKI 52466 (Cat. No. 1454). Potentiates the anticonvulsive activity of antiepileptic drugs in animal models of seizures. Orally active.
化合物库 for Talampanel
技术数据 for Talampanel
|储存||Store at +4°C|
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Talampanel
|溶剂||最高浓度 mg/mL||最高浓度 mM|
制备储备液 for Talampanel
以下数据基于产品分子量 337.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|浓度/溶剂体积/质量||1 mg||5 mg||10 mg|
|1 mM||2.96 mL||14.82 mL||29.64 mL|
|5 mM||0.59 mL||2.96 mL||5.93 mL|
|10 mM||0.3 mL||1.48 mL||2.96 mL|
|50 mM||0.06 mL||0.3 mL||0.59 mL|
参考文献 for Talampanel
Czuczwar et al (1998) LY 300164, a novel antagonist of AMPA/kainate receptors, potentiates the anticonvulsive activity of antiepileptic drugs. Eur.J.Pharmacol. 359 103 PMID: 9832379
Borowicz et al (2000) The AMPA/kainate receptor antagonist, LY 300164, increases the anticonvulsant effects of D.pam. Naunyn-Schmied.Arch.Pharmacol. 361 629 PMID: 10882038
Belayev et al (2001) Talampanel, a novel noncompetitive AMPA antagonist, is neuroprotective after traumatic brain injury in rats. J.Neurotrauma 18 1031 PMID: 11686490
If you know of a relevant reference for Talampanel, please let us know.
关键词: Talampanel, Talampanel supplier, GYKI53773, LY300164, non-competitive, AMPA/Kainate, antagonists, Glutamate, Receptors, iGlur, Ionotropic, GYKI, 53773, LY, 300164, AMPA, Kainate, 5032, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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