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Submit ReviewS 38093
Discontinued Product
6778 has been discontinued.
View all Histamine H<sub>3</sub> Receptors products.
说明： Selective H3 antagonist and inverse agonist; also σ1 receptor antagonist; antinociceptive
化学名： rel-4-[3-[(3aR,6aS)-Hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy]benzamide
纯度： ≥98% (HPLC)
生物活性 for S 38093
S 38093 is a H3 antagonist and inverse agonist (Ki values are 8.8, 1.2 and 1.44 μM, at rat, human and mouse, respectively). Exhibits no activity at other histaminergic receptors. Antagonizes agonist action at mouse H3 receptors (KB = 0.65 μM). Displays inverse agonist action in cells expressing a high H3 receptor density, (EC50 values are 9 and 1.7 μM, at human and rat H3 receptors, respectively). Exhibits antihyperalgesic effect in a mouse diabetic neuropathy model in vivo. Promotes hippocampal neurogenesis in a mouse Alzheimer's disease model. Antinociceptive and procognitive. Also σ1 receptor antagonist. Exhibits ~30-fold selecitivity for σ1 over H3 and occupies σ1 but not H3 receptors at procognitive does in mice.
技术数据 for S 38093
| 分子量 | 288.39 |
| 公式 | C17H24N2O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1403835-45-9 |
| PubChem ID | 70941112 |
| InChI Key | MRNMYWNBLVJWKG-GASCZTMLSA-N |
| Smiles | [H][C@@]12CCC[C@@]1(CN(C2)CCCOC3=CC=C(C(N)=O)C=C3)[H] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for S 38093
参考文献 for S 38093
参考文献是支持产品生物活性的出版物。
Guilloux et al (2017) S 38093, a histamine H3 antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice. Sci.Rep. 7 42946 PMID: 28218311
Chaumette et al (2018) Effects of S 38093, an antagonist/inverse agonist of histamine H3 receptors, in models of neuropathic pain in rats. Eur.J.Pain. 22 127 PMID: 28877402
Guilloux et al (2017) S 38093, a histamine H3 antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice. Sci.Rep. 7 42946 PMID: 28218311
Riddy et al (2019) Drug-receptor kinetics and sigma-1 receptor affinity differentiate clinically evaluated histamine H3 receptor antagonists. Neuropharmacology 144 244 PMID: 30359639
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关键词: S 38093, S 38093 supplier, S38093, H3, agonists, Receptors, Histamine, histaminergic, selective, antagonists, antagonism, inverse, agonism, antinociceptive, σ1, sigma1, procognitive, Sigma1, 6778, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.