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Submit ReviewRose Bengal
说明： Stains exposed epithelium in eye. Also VGlut and VMAT inhibitor
化学名： 4,5,6,7-Tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one disodium salt
纯度： ≥98% (HPLC)
生物活性 for Rose Bengal
Rose Bengal is a potent VGlut and vesicular monoamine transporter (VMAT) inhibitor (Ki values are 19 and 64 nM, respectively). Inhibits ATP dependent vesicular glutamate uptake (IC50 = 37 nM) and diminishes the amount of exocytotically released glutamate in synaptosomes. Decreases synaptic transmission in the dentate gyrus. Also stains exposed epithelium in the eye. Cell permeable.
技术数据 for Rose Bengal
| 分子量 | 1017.64 |
| 公式 | C20H2Cl4I4Na2O5 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 632-69-9 |
| PubChem ID | 32343 |
| InChI Key | UWBXIFCTIZXXLS-UHFFFAOYSA-L |
| Smiles | O=C2C(I)=CC(C(OC3=C(I)C(O[Na])=C(I)C=C34)=C2I)=C4C1=C(C(O[Na])=O)C(Cl)=C(Cl)C(Cl)=C1Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Rose Bengal
参考文献 for Rose Bengal
参考文献是支持产品生物活性的出版物。
Pietrancosta et al (2010) Rose Bengal analogs and vesicular glutamate transporters (VGLUTs). Bioorg.Med.Chem. 18 6922 PMID: 20708942
Ogita et al (2001) Inhibition of vesicular glutamate storage and exocytotic release by Rose Bengal. J Neurochem. 77 34 PMID: 11279259
Neale et al (2013) Modulation of hippocampal synaptic transmission by the kynurenine pathway member xanthurenic acid and other VGLUT inhibitors. Neuropsychopharmacology. Neuropsychopharmacology 38 1060 PMID: 23303071
Feenstra et al (1992) What is actually stained by rose bengal? Arch.Ophthalmol. 110 984 PMID: 1637285
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关键词: Rose Bengal, Rose Bengal supplier, potent, non, competitive, inhibitors, inhibits, membrane, permeable, glutamate, vesicular, transporters, VGLUT, excitatory, amino, acid, neuroprotective, Rose, Bengal, Vesicular, Monoamine, Transporters, Labels, and, Stains, Fluorescent, Transporter, Probes, 5168, Tocris Bioscience
2 篇 Rose Bengal 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Rose Bengal 的部分引用包括：
Ahmad et al (2019) Perivascular Adipocytes Store Norepinephrine by Vesicular Transport. Arterioscler Thromb Vasc Biol 39 188 PMID: 30567483
Richard et al (2022) Glycine-induced NMDA receptor internalization provides neuroprotection and preserves vasculature following ischemic stroke. iScience 25 103539 PMID: 34977503
Rose Bengal 的评论
平均评分: 5 (Based on 1 Review.)
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works well.
By
Anonymous on 03/29/2020
分析类型： In Vitro
种属： Rat
细胞系/组织： rat adrenal medulla chromaffin cells
100 μM
该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Fluorescent Dyes and Probes Research Product GuideUpdated
This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:
- Fluorescent Dyes, including Janelia Fluor® Dyes
- Fluorescent Probes for Advanced Microscopy and Live Cell Imaging
- Fluorescent Probes to Support In Vivo, Deep Tissue, and Bioluminescence Imaging
- Fluorescent Probes and Reagents for Organoids and 3D Cell Culture Imaging
- Aptamer-based RNA Imaging Reagents
- Fluorescent Probes for Imaging Bacteria
- TSA VividTM Fluorophore Kits
- TSA Reagents for Enhancing IHC, ICC & FISH Signals
- Tissue Clearing Kits and Reagents