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QM-FN-SO3

Cat. No. 7958 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

7958 has been discontinued.

说明： Blood-brain barrier penetrant, NIR aggregation-induced emission active probe of amyloid β plaques. Used for: in vitro, in situ and in vivo imaging of amyloid β plaques. Application: confocal microscopy and in vivo imaging
化学名： Sodium 3-(4-(Dicyanomethylene)-2-(2-(5-(4-(dimethylamino)phenyl)thiophen-2-yl)vinyl)quinolin-1(4H)-yl)propane-1-sulfonate
纯度： ≥95% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for QM-FN-SO3

Key information: QM-FN-SO3 is a near-infrared (NIR) aggregation-induced emission active probe for in vivo imaging of amyloid β (Aβ) plaques. Blood brain barrier penetrant.

Used for: detection of Aβ plaques in vitro, in situ and in vivo.

Application: confocal microscopy and in vivo imaging.

Properties and Photophysical Data: QM-FN-SO3 shows high binding affinity, ultra-high sensitivity, low signal-to-noise ratio, and large stokes shift (170 nm) reducing excitation light-induced self-quenching. Excitation and emission maxima (λ) are 488 nm and 680 nm, respectively.

Optical Data for QM-FN-SO3

QM-FN-SO3 Dye Spectra
λabs 488 nm
λem 680 nm
Cell Permeable Yes
Application Confocal imaging of amyloid-beta plaques, in vitro and in vivo

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

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技术数据 for QM-FN-SO3

分子量 564.65
公式 C29H25N4O3S2.Na
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2316820-94-5
PubChem ID 154727758
InChI Key WYMGXQAGHDNQOV-UEIGIMKUSA-M
Smiles CN(C)C1=CC=C(C=C1)C2=CC=C(S2)/C=C/C(N(CCCS(=O)([O-])=O)C3=C/4C=CC=C3)=CC4=C(C#N)/C#N.[Na+]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for QM-FN-SO3

参考文献是支持产品生物活性的出版物。

Yan et al (2023) Preparation of near-infrared AIEgen-active fluorescent probes for mapping amyloid-β plaques in brain tissues and living mice. Nat.Protoc. 18 1316 PMID: 36697872

Fu et al (2019) Rational design of near-infrared aggregation-induced-emission-active probes: in situ mapping of amyloid-β plaques with ultrasensitivity and high-fidelity. J.Am.Chem.Soc. 141 3171 PMID: 30632737

Su et al (2022) Strategic design of amyloid-β species fluorescent probes for Alzheimer's disease. ACS Chem.Neurosci. 13 540 PMID: 35132849

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关键词: QM-FN-SO3, QM-FN-SO3 supplier, Alzheimer's, disease, alzheimers, amyloid-β, species, near-infrared, NIR, fluorescent, probes, diagnosis, AB, amyloid-beta, beta-amyloid, aggregates, plaques, amyloidβ, amyloid, beta, brain, penetrant, peptides, Fluorescent, Amyloid, B, Probes, Beta, Peptides, 7958, Tocris Bioscience

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Fluorescent Dyes and Probes Research Product Guide

Fluorescent Dyes and Probes Research Product Guide

This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:

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  • Fluorescent Probes for Advanced Microscopy and Live Cell Imaging
  • Fluorescent Probes to Support In Vivo, Deep Tissue, and Bioluminescence Imaging
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