[Phe¹Ψ(CH₂-NH)Gly²]Nociceptin(1-13)NH₂

Name: [Phe 1 Ψ(CH 2 -NH)Gly 2 ]Nociceptin(1-13)NH 2
Brand: Tocris Bioscience
SKU: 1092

Cat. No. 1092 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1092 has been discontinued.

View all NOP Receptors products.

说明： Selective nociceptin receptor agonist

说明书

引用文献 (1)

文献 (1)

生物活性技术数据说明书参考文献

生物活性

[Phe¹Ψ(CH₂-NH)Gly²]Nociceptin(1-13)NH₂ is a potent agonist of the nociceptin (ORL₁) receptor, demonstrated both in vitro and in vivo. Selective, competitive antagonism at the nociceptin receptor has also been reported (pA₂ = 7.02 and 6.75 in the guinea pig ileum and mouse vas deferens respectively).

技术数据

分子量	1367.6
公式	C₆₁H₁₀₂N₂₂O₁₄
序列	FGGFTGARKSARK (Modifications: Phe-1 - Gly-2 peptide bond replace with Psi-(CH₂-NH), Lys-13 = C-terminal amide)
储存	Desiccate at -20°C
CAS Number	213130-17-7
PubChem ID	6324602
InChI Key	ZHKMSRDIVOXQKP-YILJZHMHSA-N
Smiles	[H]N[C@H](CNCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O)CC1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书

分析证书/产品说明书

化学品安全技术说明书

参考文献

参考文献是支持产品生物活性的出版物。

Guerrini et al (1997) Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin (1-13)-peptide amide. J.Med.Chem. 40 1789 PMID: 9191955

Guerrini et al (1998) A new selective antagonist of the nociceptin receptor. Br.J.Pharmacol. 123 163 PMID: 9489602

Okawa et al (1999) Comparison of the effects of [Phe¹ω(CH₂-NH)Gly²-nociceptin-(1-13)NH₂ in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors. Br.J.Pharmacol. 127 123 PMID: 10369464

Xu et al (1998) [Phe¹ω(CH₂-NH)Gly²-nociceptin-(1-13)NH₂, a proposed antagonist of the nociceptin receptor, is a potent and stable agonist in the rat spinal cord. Neurosci.Lett. 249 127 PMID: 9682833

按标靶查看相关产品

按产品操作查看相关产品

查看全部 NOP Receptor Agonists

关键词: [Phe1Psi(CH2-NH)Gly2]Nociceptin(1-13)NH2, [Phe1Psi(CH2-NH)Gly2]Nociceptin(1-13)NH2 supplier, Selective, nociceptin, agonists, Receptors, ORL1, OP4, NOP, Opioid, [Phe1Psi(CH2-NH)Gly2]Nociceptin(1-13)NH2, 1092, Tocris Bioscience

1 篇 [Phe¹Ψ(CH₂-NH)Gly²]Nociceptin(1-13)NH₂ 的引用文献

引用文献是使用了 Tocris 产品的出版物。 [Phe¹Ψ(CH₂-NH)Gly²]Nociceptin(1-13)NH₂ 的部分引用包括：

McLeod et al (2001) Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors. J Biol Chem 132 1175 PMID: 11250866