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NAIA

Cat. No. 8910 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Broad spectrum cysteine reactive probe; suitable for live-cell applications
别名： N-Acryloylindole-alkyne,NAIA-5
化学名： N-5-Hexyn-1-yl-2-[[1-(1-oxo-2-propen-1-yl)-1H-indol-5-yl]oxy]acetamide
纯度： ≥95% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NAIA

NAIA (N-Acryloylindole-alkyne) is a broad-spectrum cysteine reactive probe enabling cysteine profiling and imaging. It covalently binds cysteine residues in proteins.

Displays faster reaction kinetics with CYS (k > 102 M-1 s-1) and targets an expanded pool of ligandable cysteines and proteins compared to IA-Alkyne (Cat. No. 7015). Also shows higher stability and selectivity for CYS over SER and LYS than IA-Alkyne (Cat. No. 7015).

NAIA is used in chemoproteomics experiments as a click-chemistry handle to attach a fluorophore or biotin to reactive cysteines in proteins for visualization by in-gel fluorescence or identification by mass spectrometry, respectively. NAIA can also be used to image oxidized cysteines in cells under oxidative stress by confocal fluorescence microscopy.

Cell-permeable and non-cytotoxic, NAIA is suitable for live-cell experiments.

许可信息

Sold under license from Versitech Limited

技术数据 for NAIA

分子量 324.38
公式 C19H20N2O3
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 3020685-33-7
InChI Key STJKPWRTQBLLKC-UHFFFAOYSA-N
Smiles O=C(C=C)N1C=CC=2C=C(OCC(=O)NCCCCC#C)C=CC21

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NAIA

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 32.44 100

制备储备液 for NAIA

以下数据基于产品分子量 324.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.41 mL 30.83 mL
5 mM 0.62 mL 3.08 mL 6.17 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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参考文献 for NAIA

参考文献是支持产品生物活性的出版物。

Koo et al (2023) N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat. Commun 14 3564 PMID: 37322008

If you know of a relevant reference for NAIA, please let us know.

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