Lenalidomide 4'-alkylC5-azide

Pricing Availability   Qty
说明: Cereblon ligand with alkyl linker and terminal azide for onward chemistry
化学名: 3-[4-[(5-Azidopentyl)amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione
纯度: ≥95% (HPLC)
文献 (2)

生物活性 for Lenalidomide 4'-alkylC5-azide

Lenalidomide 4'-alkylC5-azide is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus an alkylC5 linker with terminal azide ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines for Lenalidomide 4'-alkylC5-azide

This product is provided for use in onward chemistry. Suitable solvents can be used.

技术数据 for Lenalidomide 4'-alkylC5-azide

分子量 370.41
公式 C18H22N6O3
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2399455-78-6
PubChem ID 151825887
Smiles [N-]=[N+]=NCCCCCNC1=C2CN(C(C2=CC=C1)=O)C3CCC(NC3=O)=O


Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Lenalidomide 4'-alkylC5-azide

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Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Ubiquitin-Proteasome System Proteins
  • Assays for Protein Degradation
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia