IDR 1002

Name: IDR 1002
Brand: Tocris Bioscience
SKU: 7866

Cat. No. 7866 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

7866 has been discontinued.

View all NF-κB and IκB products.

说明： Innate defence regulator peptide

纯度： ≥95% (HPLC)

说明书

引用文献

通路 (1)

生物活性技术数据说明书参考文献

生物活性 for IDR 1002

IDR 1002 is an innate defence regulator peptide. It reduces bacterial burden and inflammatory responses in murine models of sinusitis infection and bacterial acute lung infection. It inhibits LPS-induced NF-κB and COX-2 and induces the phosphorylation/activation of p38, ERK1/2, MSK1, and CREB.

技术数据 for IDR 1002

分子量	1652.06
公式	C₇₉H₁₃₀N₂₆O₁₃
序列	VQRWLIVWRIRK Modifications: Lys-12; C-terminal amide)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	1224095-25-3
PubChem ID	166603919
InChI Key	SEBZWKNTKRJFDZ-BRVBZNILSA-N
Smiles	O=C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C(C)C)N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for IDR 1002

分析证书/产品说明书

化学品安全技术说明书

参考文献 for IDR 1002

参考文献是支持产品生物活性的出版物。

Alford et al (2021) Murine model of sinusitis infection for screening antimicrobial and immunomodulatory therapies. Front.Cell.Infect.Microbiol. 11 621081 PMID: 33777834

Wuerth et al (2018) Characterization of host responses during pseudomonas aeruginosa acute infection in the lungs and blood and after treatment with the synthetic immunomodulatory peptide IDR-1002. Infect.Immun. 87 e00661 PMID: 30323028

Huante-Mendoza et al (2016) Peptide IDR-1002 inhibits NF-κB nuclear translocation by inhibition of IκBα degradation and activates p38/ERK1/2-MSK1-dependent CREB phosphorylation in macrophages stimulated with lipopolysaccharide. Front.Immunol. 7 533 PMID: 27933067

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关键词: IDR 1002, IDR 1002 supplier, IDR1002, antimicrobial, host-defense, peptides, inflammation, sinusitis, lung, infection, in, vivo, CREB, COX2, cytokines, IDR, innate, defence, response, peptide, p38, ERK, NF-kB/IkB, Cytokines, 7866, Tocris Bioscience

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引用文献是使用了 Tocris 产品的出版物。

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Pathways for IDR 1002

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.