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Cat.No. 7015 - IA-Alkyne | C8H12INO | CAS No. 930800-38-7
说明: Broad spectrum cysteine reactive probe
化学名: N-5-Hexyn-1-yl-2-iodoacetamide
纯度: ≥97%

生物活性 for IA-Alkyne

IA-Alkyne is a broad spectrum cysteine reactive probe. Covalently binds cysteine residues in proteins. Can be utilized for covalent fragment-based ligand discovery (FBLD) and to identify Zn2+-binding cysteines. Used as a click-chemistry handle to attach a fluorophore or biotin to reactive cysteines in proteins for visualization by in-gel fluorescence or identification by mass spectrometry, respectively. Covalently binds cysteine residues in and activates TRPA1 channels.

技术数据 for IA-Alkyne

分子量 265.09
公式 C8H12INO
储存 Store at -20°C
纯度 ≥97%
CAS Number 930800-38-7
PubChem ID 44448710


Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for IA-Alkyne

溶剂 最高浓度 mg/mL 最高浓度 mM
DMSO 26.51 100
ethanol 26.51 100

制备储备液 for IA-Alkyne

以下数据基于产品分子量 265.09。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.77 mL 18.86 mL 37.72 mL
5 mM 0.75 mL 3.77 mL 7.54 mL
10 mM 0.38 mL 1.89 mL 3.77 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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参考文献 for IA-Alkyne


Backus et al (2016) Proteome-wide covalent ligand discovery in native biological systems. Nature 534 570 PMID: 27309814

Pace and Weerapana et al (2014) A competitive chemical-proteomic platform to identify zinc-binding cysteines. ACS Chem.Biol. 9 258 PMID: 24111988

Macpherson et al (2007) Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445 541 PMID: 17237762

If you know of a relevant reference for IA-Alkyne, please let us know.


关键词: IA-Alkyne, IA-Alkyne supplier, indoacetamide, IAA, cysteines, reactive, probe, covalent, binding, binds, covalently, fragment-based, ligand, discovery, FBLD, iso-TOP-ABPP, isotopic, tandem, orthogonal, proteolysis, activity, based, protein, profiling, Biochemicals, and, Molecular, Biology, 7015, Tocris Bioscience

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