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说明： Sensitive and cell-permeable fluorogenic probe for the detection of labile Fe(II) in live cells; suitable for high-throughput assays
别名： RhoNox-4
化学名： 4-(tert-Butoxycarbonyl)-1-(3'-(4-(tert-butoxycarbonyl)piperazin-1-yl)-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-6'-yl)piperazine 1-oxide
纯度： ≥90% (HPLC)
生物活性 for FerroOrange
Key information: FerroOrange (RhoNox-4) is a highly sensitive and robust fluorogenic probe for the detection of intracellular labile Fe(II). FerroOrange displays weak absorption and low fluorescence in the visible region, but becomes strongly fluorescent upon reaction with Fe(II).
Used for: detection of intracellular labile Fe(II).
Application: high-throughput assays for high content imaging of subcellular labile Fe(II) in live cells; fluorescent microscopy; studies on iron homeostasis and ferroptosis.
Properties and Photophysical Data: FerroOrange has excellent cell-membrane permeability and low cell toxicity. FerroOrange has no chelating ability. For the fluorescent form, excitation and emission maxima (λ) measured in 50 mM HEPES buffer (pH 7.4, 0.2% DMSO) are 545 nm and 575 nm, respectively; extinction coefficient ε = 73,500 M-1cm-1; quantum yield φ = 0.19.
Optical Data for FerroOrange
| Emission Color | Orange |
|---|---|
| λabs | 545 nm |
| λem | 575 nm |
| Extinction Coefficient (ε) | 73500 M-1cm-1 |
| Quantum Yield (φ) | 0.19 |
| Cell Permeable | Yes |
| Application | High-throughput assays for the detection of intracellular labile Fe(II) |
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技术数据 for FerroOrange
| 分子量 | 684.78 |
| 公式 | C38H44N4O8 |
| 储存 | Store at +4°C |
| 纯度 | ≥90% (HPLC) |
| CAS Number | 2711762-70-6 |
| PubChem ID | 172913725 |
| InChI Key | BPPNJBCDCLJSAA-UHFFFAOYSA-N |
| Smiles | O=C1OC2(C3=C1C=CC=C3)C4=CC=C(N5CCN(CC5)C(OC(C)(C)C)=O)C=C4OC6=CC([N+]7(CCN(CC7)C(OC(C)(C)C)=O)[O-])=CC=C62 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for FerroOrange
参考文献 for FerroOrange
参考文献是支持产品生物活性的出版物。
Hirayama et al (2020) High-throughput screening for the discovery of iron homeostasis modulators using an extremely sensitive fluorescent probe. Sensors 5 2950 PMID: 32885952
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关键词: FerroOrange, FerroOrange supplier, FerroOrange, RhoNox-4, sensitive, fluorescent, fluorogenic, probe, indicator, live, cell, imaging, labile, ferrous, iron, ion, ions, Fe(II), Fe2+, high, throughput, assays, homeostasis, ferroptosis, microscopy, Fluorescent, Ion, Indicators, Live-cell, Imaging, 8846, Tocris Bioscience
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Fluorescent Dyes and Probes Research Product Guide
This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:
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- Fluorescent Probes for Advanced Microscopy and Live Cell Imaging
- Fluorescent Probes to Support In Vivo, Deep Tissue, and Bioluminescence Imaging
- Fluorescent Probes and Reagents for Organoids and 3D Cell Culture Imaging
- Aptamer-based RNA Imaging Reagents
- Fluorescent Probes for Imaging Bacteria
- TSA VividTM Fluorophore Kits
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- Tissue Clearing Kits and Reagents